The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction.

O Segatto; F Lonardo; D Wexler; F Fazioli; J H Pierce; D P Bottaro; M F White; P P Di Fiore

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The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction.

机译：表皮生长因子受体和gp185erbB-2的近膜区域决定了信号转导的特异性。

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The epidermal growth factor receptor (EGFR) and gp185erbB-2 are closely related tyrosine kinases. Despite extensive sequence and structural homology, these two receptors display quantitative and qualitative differences in their ability to couple with mitogenic signalling pathways. By using chimeric molecules between EGFR and erbB-2, we found that the determinants responsible for the specificity of mitogenic signal transduction are located in the amino-terminal half of the tyrosine kinase domain of either receptor. In the EGFR, mutational analysis within this subdomain revealed that deletion of residues 660 to 667 impaired receptor mitogenic activity without affecting its tyrosine kinase properties. This sequence is therefore likely to contribute to the specificity of substrate recognition by the EGFR kinase.

机译：表皮生长因子受体（EGFR）和gp185erbB-2是紧密相关的酪氨酸激酶。尽管有广泛的序列和结构同源性，这两种受体在与促有丝分裂信号通路耦合的能力上仍显示出数量和质量上的差异。通过使用EGFR和erbB-2之间的嵌合分子，我们发现负责有丝分裂信号转导特异性的决定因素位于任一受体酪氨酸激酶结构域的氨基末端一半。在EGFR中，该亚结构域内的突变分析表明，残基660至667的缺失损害了受体的有丝分裂活性，而不影响其酪氨酸激酶特性。因此，该序列可能有助于EGFR激酶对底物识别的特异性。

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《Molecular and Cellular Biology》 |1991年第6期|共12页
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O Segatto; F Lonardo; D Wexler; F Fazioli; J H Pierce; D P Bottaro; M F White; P P Di Fiore;
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中图分类细胞生物学;
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1. Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma. [J] . Desbois Mouthon C, Baron A, Blivet Van Eggelpoel MJ Clinical cancer research: an official journal of the American Association for Cancer Research . 2009,第17期

机译：胰岛素样生长因子-1受体抑制通过表皮生长因子受体/ HER3 / AKT信号传导途径诱导耐药机制：在肝细胞癌中共同靶向胰岛素样生长因子-1受体和表皮生长因子受体的合理依据。
2. Inhibiting Epidermal Growth Factor Receptor Dimerization and Signaling Through Targeted Delivery of a Juxtamembrane Domain Peptide Mimic [J] . Gerhart Janessa, Thevenin Anastasia F., Bloch Elizabeth, ACS Chemical Biology . 2018,第9期

机译：通过靶向递送模拟递送表皮生长因子受体二聚化和信号传导。模仿
3. Increased expression of epidermal growth factor receptor induces sequestration of extracellular signal-related kinases and selective attenuation of specific epidermal growth factor-mediated signal transduction pathways. [J] . Habib AA, Chun SJ, Neel BG, Molecular cancer research: MCR . 2003,第3期

机译：表皮生长因子受体表达的增加诱导了细胞外信号相关激酶的隔离和特定表皮生长因子介导的信号转导途径的选择性衰减。
4. Identification of regions of the epidermal growth factor receptor involved in ligand binding specificity using a high affinity form of the ectodomain [C] . E.Nice, J.Rothacker, R.Jorissen, the International Peptide Symposium . 2001

机译：使用高亲和力形式的胞外瘤的粘合性结合特异性所涉及的表皮生长因子受体的区域
5. Suppressor of cytokine signaling-2 (SOCS2) and epidermal growth factor (EGF) modulate insulin-like growth factor-I receptor (IGF-IR) signaling in intestinal cancer. [D] . Newton, Victoria A. 2010

机译：细胞因子信号传导抑制因子2（SOCS2）和表皮生长因子（EGF）的抑制因子调节肠癌中胰岛素样生长因子-I受体（IGF-IR）的信号传导。
6. The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction. [O] . O Segatto, F Lonardo, D Wexler, 1991

机译：表皮生长因子受体和gp185erbB-2的近膜区域决定了信号转导的特异性。
7. The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction. [O] . Segatto, O, Lonardo, F, Wexler, D, 1991

机译：表皮生长因子受体和gp185erbB-2的近膜区域决定了信号转导的特异性。

The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction.

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