...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular and Cellular Biology >Regulation of the cellular p53 tumor antigen in teratocarcinoma cells and their differentiated progeny.
【24h】

Regulation of the cellular p53 tumor antigen in teratocarcinoma cells and their differentiated progeny.

机译：畸胎瘤细胞及其分化后代中细胞p53肿瘤抗原的调节。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

F9 embryonal carcinoma cells express high levels of a 53,000-molecular-weight cellular tumor antigen called p53. When F9 cell cultures are treated with retinoic acid and dibutyryl adenosine 3',5'-phosphate, they differentiate, predominantly into endoderm-like cells. This differentiation is accompanied by a marked decrease in the levels of p53. The mechanism(s) responsible for this decline in the level of p53 in differentiated cells was investigated. The results demonstrate that the high levels of p53 in F9 cells relative to their differentiated progeny were not due to alterations in the stability or turnover of this protein. Rather, the regulation during differentiation involved a marked decrease in the amount of in vitro translatable p53 mRNA detected in the differentiated cell cultures. This mechanism is unlike the one operating during the simian virus 40 infection or transformation, where the increased levels of p53 are largely due to the increased stability of the p53 protein.
机译：F9胚胎癌细胞高表达53,000分子量的细胞肿瘤抗原，称为p53。当用视黄酸和二丁酰腺苷3'，5'-磷酸处理F9细胞培养物时，它们会分化为内胚层样细胞。这种分化伴随着p53水平的显着降低。研究了导致分化细胞中p53水平下降的机制。结果表明，相对于其分化后代，F9细胞中高水平的p53并非由于该蛋白的稳定性或周转率的改变。而是，分化期间的调节涉及在分化的细胞培养物中检测到的体外可翻译的p53 mRNA的量的显着减少。这种机制不同于在猿猴病毒40感染或转化过程中起作用的机制，在后者中p53的水平增加很大程度上是由于p53蛋白的稳定性增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号