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首页> 外文期刊>Molecular and Cellular Biology >Characterization of cDNA clones for the human c-yes gene.
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Characterization of cDNA clones for the human c-yes gene.

机译：人类c-yes基因的cDNA克隆的表征。

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摘要

Three c-yes cDNA clones were obtained from poly(A)+ RNA of human embryo fibroblasts. Sequence analysis of the clones showed that they contained inserts corresponding to nearly full-length human c-yes mRNA, which could encode a polypeptide of 543 amino acids with a relative molecular weight (Mr) of 60,801. The predicted amino acid sequence of the protein has no apparent membrane-spanning region or suspected ligand binding domain and closely resembles pp60c-src. Comparison of the sequences of c-yes and v-yes revealed that the v-yes gene contains most of the c-yes coding sequence except the region encoding its extreme carboxyl terminus. The region missing from the v-yes protein is the part that is highly conserved in cellular gene products of the protein-tyrosine kinase family.
机译：从人胚胎成纤维细胞的poly（A）+ RNA获得了三个c-yes cDNA克隆。克隆的序列分析表明，它们含有对应于近乎全长的人c-yes mRNA的插入片段，该片段可以编码543个氨基酸的多肽，相对分子量（Mr）为60,801。该蛋白质的预测氨基酸序列没有明显的跨膜区域或可疑的配体结合结构域，与pp60c-src非常相似。比较c-yes和v-yes的序列发现，v-yes基因包含大多数c-yes编码序列，除了编码其极端羧基末端的区域。 v-yes蛋白缺失的区域是蛋白质-酪氨酸激酶家族细胞基因产物中高度保守的部分。

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