Selective transformation of primitive lymphoid cells by the BCR/ABL oncogene expressed in long-term lymphoid or myeloid cultures.

J C Young; O N Witte

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Selective transformation of primitive lymphoid cells by the BCR/ABL oncogene expressed in long-term lymphoid or myeloid cultures.

机译：在长期淋巴或骨髓培养物中表达的BCR / ABL致癌基因选择性转化原始淋巴细胞。

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The BCR/ABL gene, formed by the Philadelphia chromosome translocation (Ph1) of human chronic myelogenous leukemia, encodes an altered ABL gene product, P210. P210 is strongly implicated in the malignant process of chronic myelogenous leukemia, but it precise role is unknown. Infection of long-term bone marrow cultures enriched for B-lymphoid cell types with a Moloney murine leukemia virus retroviral vector containing the BCR/ABL cDNA resulted in clonal outgrowths of immature B-lymphoid cells which expressed abundant P210 kinase activity. Surprisingly, infection of long-term myeloid lineage-enriched cultures also resulted in clonal outgrowths of immature B-lymphoid cells. The P210-expressing lymphoid cell lines resulting from either type of culture were resistant to the lethal effects of corticosteroids. These findings indicate that high levels of P210 expressed from a Moloney murine leukemia virus long terminal repeat preferentially stimulate the growth of immature B-lineage cells, and this effect is apparent even in myeloid lineage-enriched cultures, in which few if any lymphoid cells can be detected prior to infection.

机译：由人类慢性粒细胞性白血病的费城染色体易位（Ph1）形成的BCR / ABL基因编码一种改变的ABL基因产物P210。 P210与慢性粒细胞性白血病的恶性过程密切相关，但其确切作用尚不清楚。用含有BCR / ABL cDNA的莫洛尼鼠白血病病毒逆转录病毒载体感染富含B淋巴细胞类型的长期骨髓培养物导致未成熟的B淋巴细胞的克隆生长，该细胞表达丰富的P210激酶活性。出人意料的是，长期富含髓系谱系的培养物的感染也导致未成熟的B淋巴样细胞的克隆生长。两种培养物中产生的表达P210的淋巴样细胞系均对皮质类固醇的致死作用具有抗性。这些发现表明，从莫洛尼氏鼠白血病病毒的长末端重复序列表达的高水平P210优先刺激了未成熟B谱系细胞的生长，即使在富含髓系谱系的培养物中，淋巴样细胞也很少能在感染之前被发现。

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《Molecular and Cellular Biology》 |1988年第10期|共9页
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J C Young; O N Witte;
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中图分类细胞生物学;
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1. Bruton's tyrosine kinase is not essential for Bcr-Abl-mediated transformation of lymphoid or myeloid cells [J] . M MacPartlin, A M Smith, B J Druker, Leukemia . 2008,第7期

机译：Bruton的酪氨酸激酶对于Bcr-Abl介导的淋巴或髓样细胞转化不是必需的
2. The P190, P210, and P230 Forms of the BCR/ABL Oncogene Induce a Similar Chronic Myeloid Leukemia–like Syndrome in Mice but Have Different Lymphoid Leukemogenic Activity [J] . Shaoguang Li, Robert L. Ilaria, Ryan P. Million, The Journal of Experomental Medicine . 1999,第9期

机译：P190，P210和P230形式的BCR / ABL致癌基因在小鼠中诱发类似的慢性粒细胞样综合征，但具有不同的淋巴白血病发生活性
3. Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells. [J] . J McLaughlin, E Chianese, O N Witte Molecular and Cellular Biology . 1989,第5期

机译：BCR-ABL致癌基因的替代形式在刺激未成熟淋巴样细胞方面具有数量不同的效力。
4. Functional analysis of differential mRNAs in cancer peripheral blood: reflection of population shifts in myeloid-origin and lymphoid-origin cells [C] . Hong Guini, Li Hongdong, Zhang Wenjing, International Conference on Systems Biology . 2014

机译：癌症外周血中差异mRNA的功能分析：髓样起源和淋巴样起源细胞的群体转移的反映
5. Persistent GATA2 expression promotes self-renewal of myeloid progenitors and blocks lymphoid differentiation. [D] . Nandakumar, Satish Kumar. 2014

机译：持久的GATA2表达促进骨髓祖细胞的自我更新并阻止淋巴样分化。
6. Selective transformation of primitive lymphoid cells by the BCR/ABL oncogene expressed in long-term lymphoid or myeloid cultures. [O] . J C Young, O N Witte 1988

机译：BCR / ABL癌基因在长期淋巴或骨髓培养物中表达的原始淋巴细胞选择性转化。
7. Selective transformation of primitive lymphoid cells by the BCR/ABL oncogene expressed in long-term lymphoid or myeloid cultures. [O] . Young, J C, Witte, O N 1988

机译：BCR / ABL癌基因在长期淋巴或骨髓培养物中表达的原始淋巴细胞选择性转化。

Selective transformation of primitive lymphoid cells by the BCR/ABL oncogene expressed in long-term lymphoid or myeloid cultures.

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