Oncogenic activation of p185neu stimulates tyrosine phosphorylation in vivo.

D F Stern; M P Kamps; H Cao

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Oncogenic activation of p185neu stimulates tyrosine phosphorylation in vivo.

机译：p185neu的致癌激活在体内刺激酪氨酸磷酸化。

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p185, the product of the neu/erbB2 proto-oncogene, is oncogenically activated by a point mutation that substitutes glutamic acid for valine in the transmembrane domain of the protein. We have found that the transforming form of p185 differs from its normal counterpart in inducing increased tyrosine phosphorylation of other proteins in vivo and in having a much shorter half-life. These results support the model that the transforming p185 resembles a ligand-activated receptor.

机译：neu / erbB2原癌基因的产物p185被点突变致癌激活，该点突变用谷氨酸替代了蛋白跨膜结构域中的缬氨酸。我们已经发现，p185的转化形式不同于其正常形式，其在体内诱导其他蛋白质的酪氨酸磷酸化增加，并且半衰期短得多。这些结果支持了转化的p185类似于配体激活受体的模型。

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《Molecular and Cellular Biology》 |1988年第9期|共5页
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D F Stern; M P Kamps; H Cao;
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中图分类细胞生物学;
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专利

1. Differential tyrosine phosphorylation/activation of oncogenic proline-directed protein kinase F(A)/GSK-3alpha in well and poorly differentiated human prostate carcinoma cells. [J] . Yang CC, Hsu CP, Sheu JC, Journal of Protein Chemistry . 1998,第4期

机译：差异性酪氨酸磷酸化/激活的脯氨酸定向蛋白激酶F（A）/ GSK-3alpha在分化良好和分化较弱的人前列腺癌细胞中。
2. Differential tyrosine phosphorylation/activation of oncogenic proline-directed protein kinase F(A)/GSK-3alpha in well and poorly differentiated human prostate carcinoma cells. [J] . Yang CC, Hsu CP, Sheu JC, Journal of Protein Chemistry . 1998,第4期

机译：差异性酪氨酸磷酸化/激活的脯氨酸定向蛋白激酶F（A）/ GSK-3alpha在分化良好和分化较弱的人前列腺癌细胞中。
3. Inhibition of SRC tyrosine kinases suppresses activation of nuclear factor-kappaB, and serine and tyrosine phosphorylation of IkappaB-alpha in lipopolysaccharide-stimulated raw 264.7 macrophages. [J] . Kang JL, Lee HW, Kim HJ, Journal of toxicology and environmental health, Part A . 2005,第19期

机译：抑制SRC酪氨酸激酶可抑制核因子-κB的激活，以及脂多糖刺激的原始264.7巨噬细胞中Ikappa-α的丝氨酸和酪氨酸磷酸化。
4. Bradykinin Stimulates the Tyrosine Phosphorylation and Bradykinin 62 Receptor Association of Phospholipase Cyl in Vascular Endothelial Cells [C] . Virginia J. Venema, Jimin Sun, Douglas C. Eaton, NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling . 1999

机译：BRADYKININ刺激血管内皮细胞中磷脂脂酶酮的酪氨酸磷酸化和Bradykinin 62受体结合
5. Transforming growth factor beta-induced tyrosine phosphorylation of signal transducer and activator of transcription 3 and cellular invasion is mediated by interleukin-6 secretion in breast cancer cell lines. [D] . Parker, Nicole N. Teoh. 2009

机译：转化生长因子β诱导的酪氨酸磷酸化信号转导子和转录激活子3，以及细胞入侵是由乳腺癌细胞系中的白介素6分泌介导的。
6. Oncogenic activation of p185neu stimulates tyrosine phosphorylation in vivo. [O] . D F Stern, M P Kamps, H Cao 1988

机译：p185neu的致癌激活在体内刺激酪氨酸磷酸化。
7. EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions. [O] . D. F. Stern, M. P. Kamps 1988

机译：EGF刺激的酪氨酸磷酸化P185NEU：受体相互作用的潜在模型。
8. Increases in Tyrosine Phosphorylation Are Detectable Before Phospholipase C Activation after T Cell Receptor Stimulation. [R] . June, C. H., Fletcher, M. C., Ledbetter, J. A., 1990

机译：在T细胞受体刺激后，磷脂酶C激活前可检测到酪氨酸磷酸化的增加。

Oncogenic activation of p185neu stimulates tyrosine phosphorylation in vivo.

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