Lovastatin selectively inhibits ras activation of the 12-O-tetradecanoylphorbol-13-acetate response element in mammalian cells.

D Defeo-Jones; E M McAvoy; R E Jones; G A Vuocolo; K M Haskell; R J Wegrzyn; A Oliff

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Lovastatin selectively inhibits ras activation of the 12-O-tetradecanoylphorbol-13-acetate response element in mammalian cells.

机译：洛伐他汀在哺乳动物细胞中选择性抑制ras活化12-O-十四烷酰phorbol-13-乙酸盐响应元件。

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To evaluate ras-mediated signal transduction, an alkaline phosphatase gene (SEAP) was placed under the control of the ras-inducible phorbol ester response element (TRE) in murine fibroblasts (TRE-SEAP cells). The Kirsten ras gene was placed under the control of the glucocorticoid-inducible mouse mammary tumor virus promoter and introduced into the TRE-SEAP cells. Dexamethasone increased ras expression in the TRE-SEAP cells carrying the Kirsten ras gene and stimulated SEAP activity 25-fold. Lavostatin blocked dexamethasone induction of SEAP activity (50% inhibitory concentration, 0.5 microM) but did not affect phorbol ester-induced SEAP activity in the same cells. Lovastatin also did not block forskolin induction of SEAP activity in cells expressing SEAP under the control of the cyclic AMP response element.

机译：为了评估ras介导的信号转导，将碱性磷酸酶基因（SEAP）置于鼠成纤维细胞（TRE-SEAP细胞）中ras诱导佛波酯反应元件（TRE）的控制之下。将Kirsten ras基因置于糖皮质激素诱导的小鼠乳腺肿瘤病毒启动子的控制下，并将其引入TRE-SEAP细胞。地塞米松增加了携带Kirsten ras基因的TRE-SEAP细胞中的ras表达，并刺激了25倍的SEAP活性。 Lavostatin阻止地塞米松诱导SEAP活性（50％抑制浓度，0.5 microM），但不影响佛波酯诱导的SEAP活性。洛伐他汀在环状AMP应答元件的控制下，在表达SEAP的细胞中洛伐他汀也没有阻止福司可林诱导SEAP活性。

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《Molecular and Cellular Biology》 |1991年第4期|共4页
作者
D Defeo-Jones; E M McAvoy; R E Jones; G A Vuocolo; K M Haskell; R J Wegrzyn; A Oliff;
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中图分类细胞生物学;
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机译：洛伐他汀通过抑制肾小球系膜细胞中Ras /细胞外信号调节激酶的活性，抑制氧化的低密度脂蛋白诱导的纤溶酶原激活剂抑制剂并转化生长因子-β1表达。
2. Identification of COUP-TFII as a peroxisome proliferator response element binding factor using genetic selection in yeast: COUP-TFII activates transcription in yeast but antagonizes PPAR signaling in mammalian cells. [J] . Marcus SL, Capone JP, Rachubinski RA Molecular and Cellular Endocrinology . 1996,第1期

机译：使用酵母中的遗传选择将COUP-TFII鉴定为过氧化物酶体增殖物反应元件结合因子：COUP-TFII激活酵母中的转录，但拮抗哺乳动物细胞中的PPAR信号传导。
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机译：与激活转录因子6相关的G13（cAMP-反应元件结合蛋白相关蛋白）基因产物的鉴定，该蛋白是哺乳动物未折叠蛋白反应的转录激活因子
4. Mammalian model study of selective activation of small nerve fibres using biphasic pulses with monopolar electrode [C] . Qiang Shen, Changfeng Tai, Dazong Jiang IEEE Engineering in Medicine and Biology Annual Conference . 1999

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机译：开发雷帕霉素哺乳动物靶标的选择性抑制剂。
6. Lovastatin selectively inhibits ras activation of the 12-O-tetradecanoylphorbol-13-acetate response element in mammalian cells. [O] . D Defeo-Jones, E M McAvoy, R E Jones, 1991

机译：洛伐他汀在哺乳动物细胞中选择性抑制ras活化12-O-十四烷酰phorbol-13-乙酸盐响应元件。
7. Lovastatin selectively inhibits ras activation of the 12-O-tetradecanoylphorbol-13-acetate response element in mammalian cells. [O] . Defeo-Jones, D, McAvoy, E M, Jones, R E, 1991

机译：洛伐他汀在哺乳动物细胞中选择性抑制ras活化12-O-十四烷酰phorbol-13-乙酸盐响应元件。

Lovastatin selectively inhibits ras activation of the 12-O-tetradecanoylphorbol-13-acetate response element in mammalian cells.

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