Transcription of the mouse ribosomal spacer region.

K M Wood; L H Bowman; E A Thompson

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Transcription of the mouse ribosomal spacer region.

机译：小鼠核糖体间隔区的转录。

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This paper describes experiments designed to test the hypothesis that DNA sequences upstream from the mouse rRNA promoter are transcribed in vivo or in vitro. Plasmid pB28 contains a SalI restriction fragment that extends from -169 to -1,894 base pairs, with respect to the origin of transcription of pre-rRNA. Labeled RNA synthesized in intact cells does not hybridize to this region. Neither S1 nuclease mapping nor RNA dot blot hybridization revealed the presence of sequences complementary to this region. Transcriptional studies carried out in vitro indicated that this region is not transcribed under conditions that are optimal for utilization of the authentic rRNA promoter. Moreover, this region does not appear to form stable transcription complexes with RNA polymerase I transcription components. These data indicate that the mouse rDNA repeating unit differs from those of Xenopus spp. and Drosophila melanogaster in that reduplicated RNA polymerase I promoters are not found in the mouse rDNA spacer region.

机译：本文介绍了旨在测试以下假设的实验：小鼠rRNA启动子上游的DNA序列在体内或体外转录。质粒pB28含有相对于pre-rRNA转录起点从-169延伸至-1,894个碱基对的SalI限制性片段。在完整细胞中合成的标记RNA不与该区域杂交。 S1核酸酶作图和RNA斑点印迹杂交都没有揭示与该区域互补的序列的存在。体外进行的转录研究表明，在最适合利用真实rRNA启动子的条件下，该区域不会被转录。而且，该区域似乎不与RNA聚合酶I转录组分形成稳定的转录复合物。这些数据表明，小鼠rDNA重复单元不同于非洲爪蟾属物种。和果蝇（Drosophila melanogaster）的区别在于，在小鼠rDNA间隔区中未发现重复的RNA聚合酶I启动子。

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《Molecular and Cellular Biology》 |1984年第5期|共7页
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K M Wood; L H Bowman; E A Thompson;
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中图分类细胞生物学;
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6. Transcription of the mouse ribosomal spacer region. [O] . K M Wood, L H Bowman, E A Thompson Jr 1984

机译：小鼠核糖体间隔区的转录。
7. Transcription of the mouse ribosomal spacer region. [O] . Wood, K M, Bowman, L H, Thompson, E A 1984

机译：小鼠核糖体间隔区的转录。
8. Transcriptional Regulation of Mouse Ribosomal RNA Synthesis by Pathways InvolvingProtein Kinase C, Calcium, Insulin and Serum [R] . Grotke, M. L. 1992

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Transcription of the mouse ribosomal spacer region.

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