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首页> 外文期刊>Molecular and Cellular Biology >Regulation of immunoglobulin D synthesis in murine neonatal B lymphocytes.
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Regulation of immunoglobulin D synthesis in murine neonatal B lymphocytes.

机译：鼠新生B淋巴细胞中免疫球蛋白D合成的调控。

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We analyzed the regulatory basis for the lower expression of immunoglobulin D (IgD) in lymphocytes from neonatal mice of various ages. The results indicate that the relative transcriptional rate of RNA for delta chains is similar to adult levels even in cells which have not started to express IgD. These results suggest that very early after the initiation of mu gene transcription, a defined fraction of polymerases is programmed to progress through the termination site to the delta exons regardless of the developmental stage of the cell. Similar results were obtained from adult CBA/N mice whose spleens contain a large fraction of cells expressing low levels of IgD. On the other hand, the relative steady state level of mRNA in neonatal lymphocytes is approximately half of that in adults, suggesting that there may be differences in the processing or stability of the nascent transcript. In addition, measurements of the in vivo translation rate show that an inefficient delta polypeptide chain processing machinery in neonatal lymphocytes is also an important factor contributing to the reduced expression of IgD.
机译：我们分析了不同年龄新生小鼠淋巴细胞中免疫球蛋白D（IgD）较低表达的调控基础。结果表明，即使在尚未开始表达IgD的细胞中，δ链的RNA相对转录速率也与成年水平相似。这些结果表明，在mu基因转录开始后的很早，就定义了一定比例的聚合酶，使其通过终止位点进入δ外显子，而与细胞的发育阶段无关。从成年CBA / N小鼠的脾脏中含有大量表达低水平IgD的细胞，也获得了类似的结果。另一方面，新生儿淋巴细胞中mRNA的相对稳态水平约为成年人的一半，这表明新生转录本的加工或稳定性可能存在差异。另外，对体内翻译速率的测量表明，新生儿淋巴细胞中无效的δ多肽链加工机制也是导致IgD表达降低的重要因素。

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