首页> 外文期刊>Molecular and Cellular Biology >The cap of both miniexon-derived RNA and mRNA of trypanosomes is 7-methylguanosine.
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The cap of both miniexon-derived RNA and mRNA of trypanosomes is 7-methylguanosine.

机译:miniexon衍生的锥虫的RNA和mRNA的上限均为7-甲基鸟苷。

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Most, if not all, trypanosome mRNAs have the same 35-base sequence at their 5' terminus which is derived from a short RNA (medRNA) probably by the process of trans-splicing. It is of interest, evolutionarily and mechanistically, to determine the chemical structure of the 5' terminus of the precursor (medRNA) and product (mRNA). We demonstrate here that the cap structure of both is most probably 7-methylguanosine in a 5',5' triphosphate linkage, consistent with a precursor/product relationship.
机译:大多数(如果不是全部)锥虫mRNA在其5'末端具有相同的35个碱基的序列,可能是通过短剪接过程从短RNA(medRNA)衍生而来的。确定前体(medRNA)和产物(mRNA)的5'末端的化学结构,在进化上和机械上都是有意义的。我们在这里证明两者的帽结构很可能是在5',5'三磷酸键中的7-甲基鸟苷,与前体/产物的关系一致。

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