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首页> 外文期刊>Molecular and Cellular Biology >Cloning of a growth arrest-specific and transforming growth factor beta-regulated gene, TI 1, from an epithelial cell line.
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Cloning of a growth arrest-specific and transforming growth factor beta-regulated gene, TI 1, from an epithelial cell line.

机译：从上皮细胞系克隆生长停滞特异性和转化生长因子β调控的基因TI 1。

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摘要

By cDNA cloning and differential screening, five genes that are regulated by transforming growth factor beta (TGF beta) in mink lung epithelial cells were identified. A novel membrane protein gene, TI 1, was identified which was downregulated by TGF beta and serum in quiescent cells. In actively growing cells, the TI 1 gene is rapidly and transiently induced by TGF beta, and it is overexpressed in the presence of protein synthesis inhibitors. It appears to be related to a family of transmembrane glycoproteins that are expressed on lymphocytes and tumor cells. The four other genes were all induced by TGF beta and correspond to the genes of collagen alpha type I, fibronectin, plasminogen activator inhibitor 1, and the monocyte chemotactic cell-activating factor (JE gene) previously shown to be TGF beta regulated.
机译：通过cDNA克隆和差异筛选，鉴定了水貂肺上皮细胞中受转化生长因子β（TGF beta）调控的5个基因。鉴定了一个新的膜蛋白基因TI 1，该基因被静止细胞中的TGFβ和血清下调。在活跃生长的细胞中，TI 1基因被TGFβ迅速而短暂地诱导，并且在蛋白质合成抑制剂的存在下过表达。它似乎与在淋巴细胞和肿瘤细胞上表达的跨膜糖蛋白家族有关。其他四个基因均由TGFβ诱导，分别对应于I型胶原α，纤连蛋白，纤溶酶原激活物抑制剂1以及先前显示受TGFβ调节的单核细胞趋化性细胞激活因子（JE基因）的基因。

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