Cross-resistance to UV radiation of a cisplatin-resistant human cell line: overexpression of cellular factors that recognize UV-modified DNA.

C C Chao; S L Huang; H M Huang; S Lin-Chao

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Cross-resistance to UV radiation of a cisplatin-resistant human cell line: overexpression of cellular factors that recognize UV-modified DNA.

机译：耐顺铂人类细胞系对紫外线辐射的交叉耐药性：识别紫外线修饰DNA的细胞因子的过表达。

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A human cell line selected for cisplatin resistance (CPR) was irradiated with UV light and showed cross-resistance to UV light. Applying a modified chloramphenicol acetyltransferase assay, we observed that CPR cells acquired enhanced host cell reactivation of a transfected plasmid carrying UV damage. Gel mobility shift analysis indicated that two nuclear factors that recognize UV-modified DNA were overexpressed in CPR cells. In addition, factors that bind UV-modified DNA were independent from the factors that bind cisplatin-modified DNA. The significance of the identified binding factors, possibly DNA repair enzymes, is discussed.

机译：用UV光照射选择用于顺铂抗性（CPR）的人细胞系，并显示出对UV光的交叉抗性。应用改良的氯霉素乙酰转移酶测定法，我们观察到CPR细胞获得了带有紫外线损伤的转染质粒的增强的宿主细胞活化。凝胶迁移率迁移分析表明，识别CLP细胞的紫外线识别DNA的两个核因子过表达。另外，结合UV修饰的DNA的因子独立于结合顺铂修饰的DNA的因子。讨论了确定的结合因子，可能是DNA修复酶的意义。

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《Molecular and Cellular Biology》 |1991年第4期|共6页
作者
C C Chao; S L Huang; H M Huang; S Lin-Chao;
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中图分类细胞生物学;
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1. Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes [J] . D-w Shen, S-i Akiyama, P Schoenlein, British Journal of Cancer . 1995,第4期

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2. Identifying Apoptosis-Evasion Proteins/Pathways in Human Hepatoma Cells via Induction of Cellular Hormesis by UV Irradiation [J] . Hsieh Sen-Yung, Hsu Chih-Yun, He Jung-Ru, Journal of proteome research . 2009,第8期

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5. Winning the cellular lottery: How proteins reach and recognize targets in DNA. [D] . Redding, Sy. 2015

机译：赢得细胞彩票：蛋白质如何到达并识别DNA中的靶标。
6. Cross-resistance to UV radiation of a cisplatin-resistant human cell line: overexpression of cellular factors that recognize UV-modified DNA. [O] . C C Chao, S L Huang, H M Huang, 1991

机译：耐顺铂人类细胞系对紫外线辐射的交叉耐药性：识别紫外线修饰DNA的细胞因子的过表达。
7. Cross-resistance to UV radiation of a cisplatin-resistant human cell line: overexpression of cellular factors that recognize UV-modified DNA. [O] . Chao, C C, Huang, S L, Huang, H M, 1991

机译：耐顺铂人类细胞系对紫外线辐射的交叉耐药性：识别紫外线修饰DNA的细胞因子的过表达。

Cross-resistance to UV radiation of a cisplatin-resistant human cell line: overexpression of cellular factors that recognize UV-modified DNA.

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