...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular and Cellular Biology >The cellular response to neuregulins is governed by complex interactions of the erbB receptor family.
【24h】

The cellular response to neuregulins is governed by complex interactions of the erbB receptor family.

机译：细胞对神经调节蛋白的反应由erbB受体家族的复杂相互作用控制。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Deregulated signaling by the four members of the epidermal growth factor receptor tyrosine kinase family (erbB family) is implicated in the genesis or progression of human cancers. However, efforts to analyze signaling by these receptors have been hampered by the diversity of ligands and extensive interreceptor cross talk. We have expressed the four human erbB family receptors, singly and in pairwise combinations, in a pro-B-lymphocyte cell line (Ba/F3) and investigated the range of interactions activated by the epidermal growth factor homology domain of the agonist neuregulin beta. The results provide the first comprehensive analysis of the response of this receptor family to a single peptide agonist. This peptide induced complex patterns of receptor tyrosine phosphorylation and regulation of Ba/F3 cell survival and proliferation. These data demonstrate the existence of several previously undocumented receptor interactions driven by neuregulin.
机译：表皮生长因子受体酪氨酸激酶家族（erbB家族）的四个成员失控的信号传导与人类癌症的发生或发展有关。然而，由于配体的多样性和广泛的受体间串扰，阻碍了通过这些受体分析信号的努力。我们已经在前B淋巴细胞细胞系（Ba / F3）中单独和成对表达了四种人类erbB家族受体，并研究了激动剂神经调节蛋白β的表皮生长因子同源域激活的相互作用范围。结果提供了对该受体家族对单个肽激动剂的响应的首次综合分析。此肽诱导受体酪氨酸磷酸化和Ba / F3细胞存活和增殖调控的复杂模式。这些数据证明了由神经调节蛋白驱动的几种先前未记录的受体相互作用的存在。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号