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首页> 外文期刊>Molecular and Cellular Biology >Cooperation between the polyomavirus middle-T-antigen gene and the human c-myc oncogene in a rat thyroid epithelial differentiated cell line: model of in vitro progression.
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Cooperation between the polyomavirus middle-T-antigen gene and the human c-myc oncogene in a rat thyroid epithelial differentiated cell line: model of in vitro progression.

机译：大鼠甲状腺上皮分化细胞系中多瘤病毒中T抗原基因与人c-myc癌基因之间的合作：体外进程模型。

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摘要

Two rat thyroid epithelial differentiated cell lines, PC Cl 3 and PC myc, were infected with the polyoma murine leukemia virus (PyMLV) carrying the Middle-T-antigen gene of polyomavirus. After infection, both cell lines acquired the typical markers of neoplastic transformation; however, the PC myc cells showed a greater malignant phenotype. Furthermore, the thyroid differentiated functions were completely suppressed in PC myc cells transformed by PyMLV, whereas they were, at least partially, retained in PC Cl 3 cells transformed by PyMLV, and in particular, thyroglobulin synthesis and secretion were not affected at all. Since no differences in the expression of the middle-T-antigen gene were observed in the two PyMLV-transformed cell lines, the different properties shown by these two infected cell lines must be ascribed to the expression of the c-myc oncogene.
机译：用携带多瘤病毒的中T抗原基因的多瘤鼠白血病病毒（PyMLV）感染了两种大鼠甲状腺上皮分化细胞系PC Cl 3和PC myc。感染后，两种细胞系均获得了肿瘤转化的典型标志。然而，PC myc细胞表现出更大的恶性表型。此外，在PyMLV转化的PC myc细胞中，甲状腺分化功能被完全抑制，而它们至少部分保留在由PyMLV转化的PC Cl 3细胞中，特别是甲状腺球蛋白的合成和分泌完全不受影响。由于在两个PyMLV转化的细胞系中未观察到中间T抗原基因表达的差异，因此这两个被感染的细胞系所显示的不同特性必须归因于c-myc癌基因的表达。

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