A bcr-v-abl oncogene induces lymphomas in transgenic mice.

I K Hariharan; A W Harris; M Crawford; H Abud; E Webb; S Cory; J M Adams

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A bcr-v-abl oncogene induces lymphomas in transgenic mice.

机译：bcr-v-abl癌基因在转基因小鼠中诱导淋巴瘤。

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In chronic myeloid leukemia and some cases of acute lymphoblastic leukemia, a 9;22 chromosome translocation has fused most of the c-abl oncogene to a gene designated bcr. To explore in vivo the biological effects of the chimeric gene, we introduced a facsimile of the translocation product, a bcr-v-abl gene, into the mouse germ line under the control of the immunoglobulin heavy-chain enhancer or a retroviral long terminal repeat. Some transgenic mice bearing either construct developed clonal lymphoid tumors. T lymphomas predominated, but some pre-B lymphomas developed. The transgenes were expressed in the tumors but not detectably in the lymphoid tissues of nontumorous transgenic animals, implying that transcription is activated by a low-frequency somatic event. These results demonstrate that bcr-v-abl is tumorigenic in vivo and provide a new animal model for lymphomagenesis.

机译：在慢性粒细胞白血病和某些急性淋巴细胞白血病病例中，9; 22染色体易位已将大多数c-abl癌基因融合至一个称为bcr的基因。为了在体内探索嵌合基因的生物学效应，我们在免疫球蛋白重链增强子或逆转录病毒长末端重复序列的控制下，将易位产物bcr-v-abl基因的传真引入小鼠生殖细胞系。一些带有任一种构建体的转基因小鼠都会出现克隆性淋巴瘤。 T淋巴瘤占主导地位，但一些B前淋巴瘤发展。转基因在肿瘤中表达，但在非肿瘤转基因动物的淋巴组织中未检测到，这表明转录是由低频体细胞事件激活的。这些结果表明，bcr-v-abl在体内具有致瘤性，并为淋巴瘤的形成提供了新的动物模型。

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《Molecular and Cellular Biology》 |1989年第7期|共8页
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I K Hariharan; A W Harris; M Crawford; H Abud; E Webb; S Cory; J M Adams;
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中图分类细胞生物学;
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1. Genetic analysis of Raf1, Mdm2, c-Myc, Cdc25a and Cdc25b proto-oncogenes in 2',3'-dideoxycytidine- and 1,3-butadiene-induced lymphomas in B6C3F1 mice. [J] . Zhuang S, Soderkvist P Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2000,第1期

机译：B6C3F1小鼠2'，3'-二脱氧胞苷和1,3-丁二烯诱导的淋巴瘤中Raf1，Mdm2，c-Myc，Cdc25a和Cdc25b原癌基因的遗传分析。
2. Deregulation of the c-myc oncogene in virus-induced thymic lymphomas of AKR/J mice. [J] . A Reicin, J Q Yang, K B Marcu, Molecular and Cellular Biology . 1986,第11期

机译：病毒诱导的AKR / J小鼠病毒诱导的胸腺淋巴瘤的DEREICURACION。
3. Deregulation of the c-myc oncogene in virus-induced thymic lymphomas of AKR/J mice. [J] . A Reicin, J Q Yang, K B Marcu, Molecular and Cellular Biology . 1986,第11期

机译：病毒诱导的AKR / J小鼠病毒诱导的胸腺淋巴瘤的DEREICURACION。
4. Avian leukosis virus integrations activate oncogenes, microRNA-155, and TERT in lymphomas [C] . Withers, J.B., Bolisetty, Centennial Retrovirus Meeting . 2010

机译：禽闭锁病毒集成激活癌肠，microRNA-155和淋巴瘤的叔叔
5. Recurrent genetic alterations in thymic lymphomas of LckMyrAkt2 transgenic mice. [D] . Kashinathrao, Mamta. 2006

机译：LckMyrAkt2转基因小鼠的胸腺淋巴瘤中的复发性遗传改变。
6. A bcr-v-abl oncogene induces lymphomas in transgenic mice. [O] . I K Hariharan, A W Harris, M Crawford, 1989

机译：bcr-v-abl癌基因在转基因小鼠中诱导淋巴瘤。
7. A bcr-v-abl oncogene induces lymphomas in transgenic mice. [O] . Hariharan, I K, Harris, A W, Crawford, M, 1989

机译：bcr-v-abl癌基因在转基因小鼠中诱导淋巴瘤。
8. Results from a Study to Test the Ability of 3-acetyl-2,5-dimethylthiophene to Induce Gene Mutation in the lacZtransgene in the Liver and Duodenum of Treated Transgenic (MutaTMMouse) Mice. Perfluoroisobutyryl Fluoride. [R] . 2013

机译：用于测试3-乙酰基-2,5-二甲基噻吩诱导处理的转基因（mutaTmmouse）小鼠的肝和十二指肠中lacZ转基因的基因突变的能力的研究的结果。全氟异丁酰氟。

A bcr-v-abl oncogene induces lymphomas in transgenic mice.

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