The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells.

S F Jue; R S Bradley; J A Rudnicki; H E Varmus; A M Brown

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The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells.

机译：小鼠Wnt-1基因可以通过旁分泌机制在乳腺上皮细胞转化中起作用。

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The mouse Wnt-1 gene plays an essential role in fetal brain development and can contribute to tumorigenesis when activated aberrantly in the mammary gland. The gene encodes secretory glycoproteins associated with the extracellular or pericellular matrix, and it has been proposed that Wnt-1, as well as its Drosophila homolog wingless, may function in intercellular signalling. We show here that fibroblasts expressing Wnt-1 protein, although not transformed themselves, are able to elicit morphological transformation of neighboring C57MG mammary epithelial cells in coculture experiments. Heparin inhibits this effect, possibly by displacing Wnt-1 protein from its normal site of action. Our results indicate that the Wnt-1 gene can act via a paracrine mechanism in cell culture and strongly support the notion that in vivo the gene may function in cell-to-cell communication.

机译：小鼠Wnt-1基因在胎儿脑部发育中起着至关重要的作用，并且在乳腺中异常激活时可以促进肿瘤发生。该基因编码与细胞外或细胞外基质相关的分泌糖蛋白，并且有人提出Wnt-1及其无翅果蝇同源物可能在细胞间信号传导中起作用。我们在这里显示表达Wnt-1蛋白的成纤维细胞，尽管自身并未转化，但能够在共培养实验中引起邻近C57MG乳腺上皮细胞的形态转化。肝素可能通过从其正常作用位点置换Wnt-1蛋白来抑制此作用。我们的结果表明，Wnt-1基因可以通过旁分泌机制在细胞培养中发挥作用，并强烈支持该基因在体内可能在细胞间通讯中发挥作用的观点。

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《Molecular and Cellular Biology》 |1992年第1期|共8页
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S F Jue; R S Bradley; J A Rudnicki; H E Varmus; A M Brown;
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中图分类细胞生物学;
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1. Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line. [J] . J O Mason, J Kitajewski, H E Varmus Molecular biology of the cell . 1992,第5期

机译：小鼠Wnt-1的突变分析确定了两个温度敏感的等位基因和Wnt-1蛋白的属性，对乳腺细胞系的转化至关重要。
2. The Wnt-1 (int-1) oncogene promoter and its mechanism of activation by insertion of proviral DNA of the mouse mammary tumor virus. [J] . R Nusse, H Theunissen, E Wagenaar, Molecular and Cellular Biology . 1990,第8期

机译：Wnt-1（int-1）癌基因启动子及其通过插入小鼠乳腺肿瘤病毒的前病毒DNA激活的机制。
3. A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells. [J] . R S Bradley, A M Brown Molecular and Cellular Biology . 1995,第8期

机译：Wnt-1蛋白的可溶形式，对乳腺上皮细胞具有促有丝分裂活性。
4. Impact of miR-142-3p on mouse mammary epithelial cell proliferation and lactation [C] . H.M.Li, C.M.Wang, X.J.Gao, 3rd international symposium on dairy cow nutrition and milk quality proceedings . 2013

机译：miR-142-3p对小鼠乳腺上皮细胞增殖和泌乳的影响
5. Investigation of the intracellular signal transduction mechanisms that mediate the anticancer effects of gamma-tocotrienol in the neoplastic mouse +SA mammary epithelial cells. [D] . Samant, Ganesh Vinayak. 2006

机译：介导γ-生育三烯酚在肿瘤小鼠+ SA乳腺上皮细胞中的抗癌作用的细胞内信号转导机制的研究。
6. The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells. [O] . S F Jue, R S Bradley, J A Rudnicki, 1992

机译：小鼠Wnt-1基因可以通过旁分泌机制在乳腺上皮细胞转化中起作用。
7. The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells. [O] . Jue, S F, Bradley, R S, Rudnicki, J A, 1992

机译：小鼠Wnt-1基因可以通过旁分泌机制在乳腺上皮细胞转化中起作用。

The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells.

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