Transcriptional repression by a novel member of the bZIP family of transcription factors.

I G Cowell; A Skinner; H C Hurst

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Transcriptional repression by a novel member of the bZIP family of transcription factors.

机译：bZIP家族的一个新型转录因子抑制转录。

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We describe here a novel member of the bZIP family of DNA-binding proteins, designated E4BP4, that displays an unusual DNA-binding specificity which overlaps that of the activating transcription factor family of factors. When expressed in a transient transfection assay with a suitable reporter plasmid, E4BP4 strongly repressed transcription in a DNA-binding-site-dependent manner. Examination of a series of deletion mutants revealed that sequences responsible for the repressing potential of E4BP4 lie within the carboxyl-terminal region of the protein. No similarity was found between this region and the repressing domains of other known eukaryotic transcriptional repressors.

机译：我们在这里描述了DNA结合蛋白bZIP家族的一个新成员，命名为E4BP4，该成员显示出异常的DNA结合特异性，该特异性与因子的激活转录因子家族重叠。当在瞬时转染试验中用合适的报告质粒表达时，E4BP4以DNA结合位点依赖性的方式强烈抑制转录。对一系列缺失突变体的检查表明，负责E4BP4抑制潜力的序列位于蛋白质的羧基末端区域。在该区域与其他已知的真核转录阻遏物的阻抑域之间未发现相似性。

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《Molecular and Cellular Biology》 |1992年第7期|共8页
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I G Cowell; A Skinner; H C Hurst;
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中图分类细胞生物学;
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1. Transcriptional repression by the human bZIP factor E4BP4: definition of a minimal repression domain [J] . Helen C. Hurst, Ian G. Cowell Nucleic acids research . 1994,第1期

机译：人类bZIP因子E4BP4的转录抑制：最小抑制域的定义
2. Phylogenetic and transcriptional analysis of an expanded bZIP transcription factor family in Phytophthora sojae [J] . Wenwu Ye, Yang Wang, Suomeng Dong, BMC Genomics . 2013,第1期

机译：大豆疫霉菌中扩展的bZIP转录因子家族的系统发生和转录分析
3. Stability and DNA-binding ability of the bZIP dimers formed by the ATF-2 and c-Jun transcription factors. [J] . Carrillo RJ, Dragan AI, Privalov PL Journal of Molecular Biology . 2010,第2期

机译：由ATF-2和c-Jun转录因子形成的bZIP二聚体的稳定性和DNA结合能力。
4. FIAT, the factor-inhibiting ATF4-mediated transcription, also represses the transcriptional activity of the bZIP factor FRA-1 [C] . Rene St-Arnaud, Vice Mandic, Bilal Elchaarani Conference on Skeletal Biology and Medicine . 2010

机译：菲亚特，抑制ATF4介导的转录，还抑制了BZIP因子FRA-1的转录活性
5. Transcriptional repression mediated by a novel family of acetylene zinc finger proteins. [D] . Senawong, Thanaset. 2004

机译：新型的乙炔锌指蛋白家族介导的转录抑制。
6. Transcriptional repression by a novel member of the bZIP family of transcription factors. [O] . I G Cowell, A Skinner, H C Hurst 1992

机译：bZIP家族的一个新型转录因子抑制转录。
7. Transcriptional repression by a novel member of the bZIP family of transcription factors. [O] . Cowell, I G, Skinner, A, Hurst, H C 1992

机译：bZIP家族的一个新型转录因子抑制转录。
8. Inhibition of Breast Cancer by Repression of Angiogenic Hypoxia- Inducible Transcription Factors. [R] . Bedi, A. 2001

机译：抑制血管生成缺氧诱导转录因子抑制乳腺癌。

Transcriptional repression by a novel member of the bZIP family of transcription factors.

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