The yeast alpha 2 protein can repress transcription by RNA polymerases I and II but not III.

B M Herschbach; A D Johnson

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The yeast alpha 2 protein can repress transcription by RNA polymerases I and II but not III.

机译：酵母alpha 2蛋白可以抑制RNA聚合酶I和II的转录，但不能抑制III。

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The alpha 2 protein of the yeast Saccharomyces cerevisiae normally represses a set of cell-type-specific genes (the a-specific genes) that are transcribed by RNA polymerase II. In this study, we determined whether alpha 2 can affect transcription by other RNA polymerases. We find that alpha 2 can repress transcription by RNA polymerase I but not by RNA polymerase III. Additional experiments indicate that alpha 2 represses RNA polymerase I transcription through the same pathway that it uses to repress RNA polymerase II transcription. These results implicate conserved components of the transcription machinery as mediators of alpha 2 repression and exclude several alternate models.

机译：酵母啤酒酵母的α2蛋白通常抑制RNA聚合酶II转录的一组细胞类型特异性基因（α特异性基因）。在这项研究中，我们确定了alpha 2是否可以影响其他RNA聚合酶的转录。我们发现alpha 2可以抑制RNA聚合酶I的转录，但不能抑制RNA聚合酶III的转录。其他实验表明，alpha 2通过与抑制RNA聚合酶II转录相同的途径抑制RNA聚合酶I转录。这些结果暗示了转录机械的保守成分作为α2抑制的中介，并排除了几种替代模型。

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《Molecular and Cellular Biology》 |1993年第7期|共10页
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B M Herschbach; A D Johnson;
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中图分类细胞生物学;
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1. Insights into transcription initiation and termination from the electron microscopy structure of yeast RNA polymerase III. [J] . Fernandez-Tornero C, Bottcher B, Riva M, Molecular cell . 2007,第6期

机译：从酵母RNA聚合酶III的电子显微镜结构了解转录的起始和终止。
2. ret1-1, a yeast mutant affecting transcription termination by RNA polymerase III. [J] . B D Hall, P James Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 1990,第2期

机译：ret1-1，一种影响RNA聚合酶III终止转录的酵母突变体。
3. Defects in the NC2 repressor affect both canonical and non-coding RNA polymerase II transcription initiation in yeast [J] . Natalia Gómez-Navarro, Antonio Jordán-Pla, Francisco Estruch, BMC Genomics . 2016,第1期

机译：NC2阻遏物的缺陷影响酵母中的规范和非编码RNA聚合酶II转录起始
4. Activation by c-Myc of transcription by RNA polymerases I,II and III [C] . Natividad Gomez-Roman, Zoe A.Felton-Edkins, Niall S.Kenneth Biochemical Society Symposium . 2006

机译：通过RNA聚合酶I，II和III的转录C-MYC激活
5. The structural studies of protein translation: Yeast phenylalanine transfer RNA and elongation factor G domain III. [D] . Shi, Huijing. 2000

机译：蛋白质翻译的结构研究：酵母苯丙氨酸转移RNA和延伸因子G结构域III。
6. The yeast alpha 2 protein can repress transcription by RNA polymerases I and II but not III. [O] . B M Herschbach, A D Johnson 1993

机译：酵母α2蛋白可以抑制RNA聚合酶I和II的转录但不能抑制III。
7. The yeast alpha 2 protein can repress transcription by RNA polymerases I and II but not III. [O] . Herschbach, B M, Johnson, A D 1993

机译：酵母α2蛋白可以抑制RNA聚合酶I和II的转录，但不能抑制III。

The yeast alpha 2 protein can repress transcription by RNA polymerases I and II but not III.

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