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首页> 外文期刊>Molecular and Cellular Biology >A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.
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A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.

机译：通过替代的mRNA剪接产生肌肉特异性同工型的Mef2基因。

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Members of the myocyte-specific enhancer-binding factor 2 (MEF2) family of transcription factors bind a conserved A/T-rich sequence in the control regions of numerous muscle-specific genes. Mammalian MEF2 proteins have been shown previously to be encoded by three genes, Mef2, xMef2, and Mef2c, each of which gives rise to multiple alternatively spliced transcripts. We describe the cloning of a new member of the MEF2 family from mice, termed MEF2D, which shares extensive homology with other MEF2 proteins but is the product of a separate gene. MEF2D binds to and activates transcription through the MEF2 site and forms heterodimers with other members of the MEF2 family. Deletion mutations show that the carboxyl terminus of MEF2D is required for efficient transactivation. MEF2D transcripts are widely expressed, but alternative splicing of MEF2D transcripts gives rise to a muscle-specific isoform which is induced during myoblast differentiation. The mouse Mef2, Mef2c, and Mef2d genes map to chromosomes 7, 13, and 3, respectively. The complexity of the MEF2 family of regulatory proteins provides the potential for fine-tuning of transcriptional responses as a consequence of combinatorial interactions among multiple MEF2 isoforms encoded by the four Mef2 genes.
机译：转录因子的肌细胞特异性增强子结合因子2（MEF2）家族的成员在许多肌肉特异性基因的控制区域中结合了一个保守的富含A / T的序列。哺乳动物MEF2蛋白质先前已显示由三个基因Mef2，xMef2和Mef2c编码，每个基因都产生多个选择性剪​​接的转录本。我们描述了从小鼠克隆的MEF2家族的新成员，称为MEF2D，与其他MEF2蛋白具有广泛的同源性，但是一个独立基因的产物。 MEF2D结合并激活通过MEF2位点的转录，并与MEF2家族的其他成员形成异二聚体。缺失突变表明MEF2D的羧基末端是有效的反式激活所必需的。 MEF2D转录物被广泛表达，但MEF2D转录物的可变剪接产生了成肌细胞分化过程中诱导的肌肉特异性同种型。小鼠Mef2，Mef2c和Mef2d基因分别映射到7、13和3号染色体。由于由四个Mef2基因编码的多个MEF2同工型之间的组合相互作用，MEF2调节蛋白家族的复杂性提供了微调转录反应的潜力。

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