Differential expression of porcine major histocompatibility DNA sequences introduced into mouse L cells.

M L Satz; D S Singer

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Differential expression of porcine major histocompatibility DNA sequences introduced into mouse L cells.

机译：导入小鼠L细胞的猪主要组织相容性DNA序列的差异表达。

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The expression of a porcine genomic DNA segment containing a major histocompatibility gene and its chromatin structure in mouse L cells have been investigated. The transformed cells, which contain about two copies of the 17.8-kilobase pig DNA insert per haploid genome, stably and uniformly express major histocompatibility antigen on their surfaces. This expression is the result of differential transcription of the 3-kilobase major histocompatibility gene; the other 14 kilobases of pig sequences flanking the coding sequence are not transcribed. Although the entire pig DNA segment is packaged into nucleosomes, only the transcriptionally active DNA sequences are packaged in a DNase I-sensitive conformation. These results suggest that the expression of this foreign DNA is actively regulated in L cells.

机译：已经研究了包含主要组织相容性基因的猪基因组DNA片段在小鼠L细胞中的表达及其染色质结构。每个单倍体基因组包含大约两个拷贝的17.8千碱基的猪DNA插入片段的转化细胞在其表面上稳定且均一地表达主要的组织相容性抗原。这种表达是3-kilobase主要组织相容性基因差异转录的结果。位于编码序列侧翼的其他14 kb猪序列不被转录。尽管整个猪DNA片段都包装在核小体中，但只有转录活性DNA序列才以DNase I敏感的构象包装。这些结果表明该外源DNA的表达在L细胞中受到主动调节。

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《Molecular and Cellular Biology》 |1983年第11期|共11页
作者
M L Satz; D S Singer;
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中图分类细胞生物学;
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1. The induction of major histocompatibility complex class II expression is sufficient for the direct activation of human CD4+ T cells by porcine vascular endothelial cells. [J] . Yun S, Rose ML, Fabre JW Transplantation: Official Journal of the Transplantation Society . 2000,第5期

机译：诱导主要组织相容性复合物II类表达足以通过猪血管内皮细胞直接激活人CD4 + T细胞。
2. Differential effects of protein tyrosine kinase inhibitors on interferon-gamma-induction of major histocompatibility complex class II and intercellular adhesion molecule-1 expression in human corneal epithelial cells. [J] . Iwata M, Suzuki Y, Imai Y, Japanese Journal of Ophthalmology . 2001,第1期

机译：蛋白质酪氨酸激酶抑制剂对人角膜上皮细胞中主要组织相容性复合物II类干扰素-γ诱导和细胞间粘附分子1表达的差异作用。
3. Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes. [J] . T Nakamura, D M Donovan, K Hamada, Molecular and Cellular Biology . 1990,第7期

机译：小鼠αA-晶状体蛋白基因的调控：分离编码与主要组织相容性复合体I类基因和其他基因共享的顺式序列基序的蛋白质的cDNA。
4. Effects of major histocompatibility complex class II knockout on mouse mechanical properties during development [C] . Steven J. Simske, Ted A. Bateman, Erin E. Smith, Annual Rocky Mountain Bioengineering Symposium . 2002

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5. The major histocompatibility complex in mouse embryos and embryonic stem cells. [D] . Lampton, Paula Welter. 2008

机译：小鼠胚胎和胚胎干细胞中的主要组织相容性复合物。
6. Differential expression of porcine major histocompatibility DNA sequences introduced into mouse L cells. [O] . M L Satz, D S Singer 1983

机译：导入小鼠L细胞的猪主要组织相容性DNA序列的差异表达。
7. Differential expression of porcine major histocompatibility DNA sequences introduced into mouse L cells. [O] . Satz, M L, Singer, D S 1983

机译：导入小鼠L细胞的猪主要组织相容性DNA序列的差异表达。
8. Molecular Analysis of the Induction of Class II Major Histocompatibility Antigen Expression on Murine Macrophages by Interferon-Gamma and Its Down-Regulation by Interferon-Alpha/Beta and Dexamethasone. [R] . Ruggio, D. F. 1989

机译：干扰素-γ诱导小鼠巨噬细胞II类主要组织相容性抗原表达的分子分析及干扰素-α/β和地塞米松的下调。

Differential expression of porcine major histocompatibility DNA sequences introduced into mouse L cells.

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