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首页> 外文期刊>Molecular and Cellular Biology >Structure of the c-Ki-ras gene in a rat fibrosarcoma induced by 1,8-dinitropyrene.
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Structure of the c-Ki-ras gene in a rat fibrosarcoma induced by 1,8-dinitropyrene.

机译:1,8-二硝基py诱导的大鼠纤维肉瘤中c-Ki-ras基因的结构。

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摘要

Restriction enzyme maps were made of the region around exons 1 and 2 of activated c-Ki-ras of a fibrosarcoma (1,8-DNP2) induced in a rat by 1,8-dinitropyrene. Nucleotide sequence analysis revealed that activated c-Ki-ras shows a G----T transversion in codon 12 and consequently encodes cysteine instead of glycine in normal rat c-Ki-ras.
机译:限制酶图谱是由1,8-二硝基py在大鼠中诱导的纤维肉瘤(1,8-DNP2)的活化c-Ki-ras的外显子1和2附近的区域。核苷酸序列分析表明,活化的c-Ki-ras在正常大鼠c-Ki-ras中显示出密码子12中的G ---- T反转,因此编码半胱氨酸而不是甘氨酸。

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