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首页> 外文期刊>Molecular and Cellular Biology >Expression of six mouse major urinary protein genes in the mammary, parotid, sublingual, submaxillary, and lachrymal glands and in the liver.
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Expression of six mouse major urinary protein genes in the mammary, parotid, sublingual, submaxillary, and lachrymal glands and in the liver.

机译：在乳腺，腮腺，舌下，颌下，泪腺和肝脏中六个小鼠主要尿蛋白基因的表达。

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Mouse major urinary proteins (MUPs) are encoded by a family of about 35 to 40 highly conserved genes. In the preceding paper (K. Shahan, M. Gilmartin, and E. Derman, Mol. Cell. Biol. 7:1938-1946, 1987), we presented the sequences of the most abundant MUP mRNAs in the liver (MUP I, II, and III) and in the lachrymal (MUP IV) and submaxillary (MUP V) glands. We have shown that these five mRNAs are coded by five distinct genes, MUP I through V. In the present communication, we examine the expression of MUP genes in all of the six tissues in which MUP mRNAs are synthesized, the mammary, parotid, sublingual, lachrymal, and submaxillary glands and the liver. We show that gene MUP II is expressed in the liver and in the mammary gland, that gene MUP IV is expressed in the lachrymal and parotid glands, and that gene MUP V is expressed in the submaxillary, sublingual, and lachrymal and parotid glands, and that gene MUP V is expressed in the submaxillary, sublingual, and lachrymal glands. Furthermore, we present evidence that in addition to genes MUP I through V, another gene, MUP VI, is expressed in BALB/c mice in the parotid gland. The tissue-specific synthesis of MUP mRNAs is thus brought about by two major mechanisms: the expression, in different tissues, of different members of the family and the expression of a single gene at various levels in different tissues. When a particular MUP gene is expressed in several tissues, transcripts of this gene initiate at the same site and are spliced and polyadenylated in the same manner.
机译：小鼠主要尿蛋白（MUPs）由大约35至40个高度保守的基因家族编码。在之前的论文（K. Shahan，M. Gilmartin和E. Derman，Mol。Cell。Biol。7：1938-1946，1987）中，我们介绍了肝脏中最丰富的MUP mRNA的序列（MUP I， II和III）以及泪腺（MUP IV）和上颌下腺（MUP V）。我们已经显示这五个mRNA由五个不同的基因MUP I至V编码。在本交流中，我们检查了MUP基因在所有合成MUP mRNA的六个组织（乳腺，腮腺，舌下）中的表达。 ，泪腺和颌下腺和肝脏。我们显示基因MUP II在肝脏和乳腺中表达，基因MUP IV在泪腺和腮腺中表达，而基因MUP V在上颌下，舌下，泪腺和腮腺中表达，并且MUP V基因在上颌下，舌下和泪腺中表达。此外，我们提供的证据表明，除了MUP I至V基因外，另一基因MUP VI在腮腺的BALB / c小鼠中表达。因此，MUP mRNA的组织特异性合成是通过两种主要机制实现的：在不同组织中表达该家族的不同成员，以及在不同组织中表达不同水平的单个基因。当特定的MUP基因在几种组织中表达时，该基因的转录本会在同一位点起始，并以相同的方式进行剪接和聚腺苷酸化。

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