Expression and regulation of the pituitary- and placenta-specific human glycoprotein hormone alpha-subunit gene is restricted to the pituitary in transgenic mice.

N Fox; D Solter

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Expression and regulation of the pituitary- and placenta-specific human glycoprotein hormone alpha-subunit gene is restricted to the pituitary in transgenic mice.

机译：垂体和胎盘特异性人糖蛋白激素α-亚基基因的表达和调控仅限于转基因小鼠的垂体。

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Expression of the glycoprotein hormone alpha subunit occurs in both the pituitary and placenta in humans. However, this study found that expression of this subunit is restricted to the pituitary in mice. An interspecies analysis of human alpha-subunit gene regulation was undertaken, using the transgenic-mouse approach. In mice transgenic for a genomic clone containing the complete human alpha-subunit gene and several kilobases of 5'- and 3'-flanking sequences, cell-type-specific expression and hormonal regulation of the human alpha-subunit transgene occurred in the mouse pituitary, whereas no expression of the transgene was detectable in the mouse placenta. These findings provide strong evidence that a common trans-acting factor(s) regulates glycoprotein hormone alpha-subunit gene expression in the human and mouse pituitaries; however, this factor(s) or a unique factor(s), though functional in the human placenta, is either nonfunctional or absent in the mouse placenta.

机译：糖蛋白激素α亚基的表达在人的垂体和胎盘中均发生。但是，这项研究发现该亚基的表达仅限于小鼠的垂体。使用转基因小鼠方法进行了人类α-亚基基因调控的种间分析。在转基因小鼠的基因组克隆中，该基因组克隆包含完整的人α-亚基基因和几千碱基的5'-和3'-侧翼序列，人垂体中发生了细胞类型特异性表达和荷尔蒙调节，而在小鼠胎盘中未检测到转基因的表达。这些发现提供了有力的证据，证明一种常见的反式作用因子调节人和小鼠垂体中糖蛋白激素α-亚基基因的表达。但是，尽管该因子或独特因子在人胎盘中具有功能，但在小鼠胎盘中却不起作用或不存在。

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《Molecular and Cellular Biology》 |1988年第12期|共7页
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N Fox; D Solter;
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中图分类细胞生物学;
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1. Expression of the glycoprotein hormone alpha-subunit gene in the placenta requires a functional cyclic AMP response element, whereas a different cis-acting element mediates pituitary-specific expression. [J] . J A Bokar, R A Keri, T A Farmerie, Molecular and Cellular Biology . 1989,第11期

机译：糖蛋白激素α-亚基基因在胎盘中的表达需要功能性的环状AMP反应元件，而不同的顺式作用元件介导垂体特异性表达。
2. Tissue-specific gene expression in the pituitary: the glycoprotein hormone alpha-subunit gene is regulated by a gonadotrope-specific protein. [J] . F Horn, J J Windle, K M Barnhart, Molecular and Cellular Biology . 1992,第5期

机译：垂体中的组织特异性基因表达：糖蛋白激素α-亚基基因受促性腺激素特异性蛋白调节。
3. The highly related LIM factors, LMO1, LMO3 and LMO4, play different roles in the regulation of the pituitary glycoprotein hormone alpha-subunit (alpha GSU) gene [J] . Susa T, Ishikawa A, Cai LY, Bioscience Reports . 2010,第1期

机译：高度相关的LIM因子LMO1，LMO3和LMO4在垂体糖蛋白激素α亚基（alpha GSU）基因的调节中起不同作用
4. The Hormone Response Element (HRE) of the Human ApoCIII Enhancer Is Essential for the Intestinal Expression of the Human Apoa-I Gene in Transgenic Mice [C] . Horng Yuan Kan, Spiros Georgopoulos, Eleni Zanni, NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling . 1999

机译：人Apociii Enhancer的激素应答元件（HRE）对于转基因小鼠中人Apoa-I基因的肠道表达至关重要
5. Plasticity of pituitary hormone secretion, expression and cell numbers within the anterior pituitary glands of human growth hormone-releasing hormone transgenic mice: Focus on galanin, growth hormone, and prolactin. [D] . Moore, Joseph Patrick, Jr. 1997

机译：人类生长激素释放激素转基因小鼠的垂体前叶垂体激素分泌，表达和细胞数量的可塑性：专注于甘丙肽，生长激素和催乳激素。
6. Expression and regulation of the pituitary- and placenta-specific human glycoprotein hormone alpha-subunit gene is restricted to the pituitary in transgenic mice. [O] . N Fox, D Solter 1988

机译：垂体和胎盘特异性人糖蛋白激素α-亚基基因的表达和调控仅限于转基因小鼠的垂体。
7. Expression and regulation of the pituitary- and placenta-specific human glycoprotein hormone alpha-subunit gene is restricted to the pituitary in transgenic mice. [O] . Fox, N, Solter, D 1988

机译：垂体和胎盘特异性人糖蛋白激素α-亚基基因的表达和调控仅限于转基因小鼠的垂体。
8. Mechanism of Hormonal Regulation of CAD Gene Expression in Human Breast Cancer Cells [R] . 2006

机译：人乳腺癌细胞CaD基因表达的激素调节机制

Expression and regulation of the pituitary- and placenta-specific human glycoprotein hormone alpha-subunit gene is restricted to the pituitary in transgenic mice.

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