Differential expression of type-specific c-abl mRNAs in mouse tissues and cell lines.

M W Renshaw; M A Capozza; J Y Wang

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Differential expression of type-specific c-abl mRNAs in mouse tissues and cell lines.

机译：类型特异性c-abl mRNA在小鼠组织和细胞系中的差异表达。

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The mammalian c-abl proto-oncogene produces mRNAs with 5' heterogeneity from two distinct promoters and the alternative splicing of variable 5' exons. By using quantitative RNase protection assays, the relative abundance of two major c-abl mRNAs, type I and type IV, in several mouse tissues and cell lines has been determined. Our results demonstrate that the level of type IV c-abl mRNA is rather constant, whereas that of the type I mRNA varies over a 10-fold range in different tissues and cell types. This finding has interesting implications for the function of the two c-abl proteins.

机译：哺乳动物c-abl原癌基因从两个不同的启动子和可变5'外显子的可变剪接处产生具有5'异质性的mRNA。通过使用定量RNase保护测定，已经确定了几种小鼠组织和细胞系中两个主要的c-abl mRNA（I型和IV型）的相对丰度。我们的结果证明，IV型c-abl mRNA的水平相当稳定，而I型mRNA的水平在不同的组织和细胞类型中变化了10倍。该发现对两种c-abl蛋白的功能具有有趣的意义。

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《Molecular and Cellular Biology》 |1988年第10期|共5页
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M W Renshaw; M A Capozza; J Y Wang;
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中图分类细胞生物学;
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Differential expression of type-specific c-abl mRNAs in mouse tissues and cell lines.

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