Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma cell line.

D M Zaller; H Yu; L A Eckhardt

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Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma cell line.

机译：T淋巴瘤细胞系对在免疫球蛋白增强子或启动子存在下激活的基因产生负调控。

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The tissue-specific expression of immunoglobulin genes can be partially explained by a requirement for activating factors found only in B lymphocytes and their derivatives. However, loss of immunoglobulin expression upon fusion of an immunoglobulin-producing myeloma cell with a T lymphoma cell (BW5147) or fibroblast (L cell) suggests that negatively acting factors also play a role in the tissue specificity of immunoglobulin genes. Expression of a cloned immunoglobulin heavy-chain gene introduced into myeloma cells was suppressed after fusion of the myeloma transformants with BW5147. The presence of either the immunoglobulin heavy-chain enhancer or promoter conferred suppression, under similar conditions, upon a heterologous gene that is normally expressed in both B and T lymphocytes. These immunoglobulin heavy-chain gene control regions, or gene modifications induced by them, are subject to negative control by T-lymphocyte-derived factors.

机译：免疫球蛋白基因的组织特异性表达可以由仅在B淋巴细胞及其衍生物中发现的激活因子的需求来部分解释。然而，在产生免疫球蛋白的骨髓瘤细胞与T淋巴瘤细胞（BW5147）或成纤维细胞（L细胞）融合后，免疫球蛋白表达的丧失表明负作用因子也在免疫球蛋白基因的组织特异性中起作用。在骨髓瘤转化体与BW5147融合后，抑制了导入骨髓瘤细胞的克隆的免疫球蛋白重链基因的表达。免疫球蛋白重链增强子或启动子的存在在相似条件下可抑制通常在B和T淋巴细胞中均表达的异源基因。这些免疫球蛋白重链基因控制区或由它们诱导的基因修饰受到T淋巴细胞衍生因子的阴性控制。

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《Molecular and Cellular Biology》 |1988年第5期|共8页
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D M Zaller; H Yu; L A Eckhardt;
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中图分类细胞生物学;
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3. Early B-cell factor (EBF) down-regulates immunoglobulin heavy chain intron enhancer function in a plasmacytoma cell line. [J] . Akerblad P, Sigvardsson M, Leanderson T Scandinavian journal of immunology. . 1996,第1期

机译：早期B细胞因子（EBF）下调浆细胞瘤细胞系中的免疫球蛋白重链内含子增强子功能。
4. "Promoter Array" Studies Identify Cohorts of Genes Directly Regulated by Methylation, Copy Number Change, or Transcription Factor Binding in Human Cancer Cells [C] . YIPENG WANG, JUN HAYAKAWA, FRED LONG, NIH Symposium on Therapeutic Oligonucleotides . 2005

机译：“启动子阵列”研究鉴定了通过甲基化，拷贝数变化或人癌细胞中的转录因子结合直接调节的基因的群组
5. Analysis of cis- andtrans-acting factors that differentially regulate two highly homologous promoters in the immunoglobulin locus. [D] . Dryer-Minnerly, Rebecca L. 2006

机译：分析在免疫球蛋白基因座中差异调节两个高度同源启动子的顺式和反式作用因子。
6. Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma cell line. [O] . D M Zaller, H Yu, L A Eckhardt 1988

机译：在T淋巴瘤细胞系中负调控免疫球蛋白增强子或启动子的存在而激活的基因。
7. Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma cell line. [O] . Zaller, D M, Yu, H, Eckhardt, L A 1988

机译：在T淋巴瘤细胞系中负调控免疫球蛋白增强子或启动子的存在而激活的基因。

Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma cell line.

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