Nuclear Inheritance of Erythromycin Resistance in Human Cells: New Class of Mitochondrial Protein Synthesis Mutants

Claus-Jens Doersen; Eric J. Stanbridge

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Nuclear Inheritance of Erythromycin Resistance in Human Cells: New Class of Mitochondrial Protein Synthesis Mutants

机译：人类细胞对红霉素抗性的核遗传：新型线粒体蛋白合成突变体。

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The characterization of two new erythromycin-resistant mutants of HeLa cells is described. The strains ERY2305 and ERY2309 both exhibited resistance to erythromycin in growth assays and cell-free mitochondrial protein synthesis assays. The erythromycin resistance phenotype could not be transferred by cybridization. The mutation appeared to be encoded in the nucleus and inherited as a recessive trait. These two mutants, therefore, represent a new class of erythromycin-resistant mutants in human cells that is distinct from the cytoplasmically inherited mutation in strain ERY2301 described previously.

机译：描述了两个新的抗HeLa细胞红霉素突变体的特征。在生长测定和无细胞线粒体蛋白质合成测定中，菌株ERY2305和ERY2309均显示出对红霉素的抗性。红霉素抗性表型不能通过杂交转移。该突变似乎被编码在细胞核中并作为隐性性状遗传。因此，这两个突变体代表了人类细胞中一类新的抗红霉素突变体，与先前所述的ERY2301菌株的细胞质遗传突变不同。

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《Molecular and Cellular Biology》 |1982年第6期|共7页
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Claus-Jens Doersen; Eric J. Stanbridge;
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中图分类细胞生物学;
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1. High-activity p-glycoprotein, multidrug resistance protein 2, and breast cancer resistance protein membrane vesicles prepared from transiently transfected human embryonic kidney 293-epstein-barr virus nuclear antigen cells. [J] . Karlsson JE, Heddle C, Rozkov A, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2010,第4期

机译：由瞬时转染的人胚肾293-爱泼斯坦-巴尔病毒核抗原细胞制备的高活性p-糖蛋白，多药抗性蛋白2和乳腺癌抗性蛋白膜囊泡。
2. The erythromycin-resistance in S. pyogenes does not limit the human polymorphonuclear cell and antimicrobial activity [J] . CuffiniA.M., TullioV., BancheG., International journal of immunopathology and pharmacology. . 2009,第1期

机译：化脓性链球菌中的红霉素抗性不限制人类多形核细胞和抗菌活性
3. Differences in the products of mitochondrial protein synthesis in vivo in human and mouse cells and their potential use as markers for the mitochondrial genome in human–mouse cell hybrids [J] . Alec Jeffreys, Ian Craig The biochemical journal . 1974,第1期

机译：人和小鼠细胞中体内线粒体蛋白质合成产物的差异及其在人-鼠细胞杂种中线粒体基因组标记的潜在用途
4. Mining Human Mitochondrial and Mitochondrial Associated Proteins based on SVM and Neural Network [C] . Guangrong Li, Zhong Huang, Jiali Xia, International Conference on Granular Computing . 2008

机译：基于SVM和神经网络的挖掘人体线粒体和线粒体相关蛋白
5. Studies of proliferating cell nuclear antigen mutant proteins defective in translesion synthesis and mismatch repair [D] . Dieckman, Lynne Margaret 2013

机译：在转移合成和错配修复中有缺陷的增殖细胞核抗原突变蛋白的研究
6. Nuclear Inheritance of Erythromycin Resistance in Human Cells: New Class of Mitochondrial Protein Synthesis Mutants [O] . Claus-Jens Doersen, Eric J. Stanbridge 1982

机译：人类细胞对红霉素抗性的核遗传：线粒体蛋白质合成突变的新类别。
7. Nuclear Inheritance of Erythromycin Resistance in Human Cells: New Class of Mitochondrial Protein Synthesis Mutants [O] . Doersen, Claus-Jens, Stanbridge, Eric J. 1982

机译：人类细胞对红霉素抗性的核遗传：线粒体蛋白质合成突变的新类别。

Nuclear Inheritance of Erythromycin Resistance in Human Cells: New Class of Mitochondrial Protein Synthesis Mutants

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