Dependence of nucleus-directed rRNA synthesis upon mitochondrial protein synthesis in Tetrahymena.

L Ruben; A B Hooper

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Dependence of nucleus-directed rRNA synthesis upon mitochondrial protein synthesis in Tetrahymena.

机译：四核膜中核定向rRNA合成对线粒体蛋白质合成的依赖性。

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The antibiotic chloramphenicol selectively inhibited mitochondrial protein synthesis in the ciliate protozoan Tetrahymena pyriformis GL. Secondary to the inhibition of mitochondrial protein synthesis was an inhibition of nuclear RNA synthesis at a time before inhibition of cellular protein and DNA synthesis. Of the stable non-polyadenylated RNA species in Tetrahymena, the addition of chloramphenicol resulted specifically in the inhibition of synthesis of 28S + 17S and 5S rRNA transcripts. By contrast, syntheses of 4S tRNA and 21S mitochondrial rRNA were not as extensively inhibited. The addition of 60 microM hemin before the addition of chloramphenicol partially protected against the inhibition of RNA synthesis. These data indicate that continued synthesis of nucleus-directed rRNA is linked to the synthesis of mitochondrial proteins in Tetrahymena.

机译：抗生素氯霉素选择性抑制纤毛虫原生动物四膜虫GL中的线粒体蛋白合成。抑制线粒体蛋白质合成的次要因素是抑制细胞蛋白质和DNA合成之前对核RNA合成的抑制。在四膜虫中稳定的非聚腺苷酸化的RNA物种中，氯霉素的添加特异性地抑制了28S + 17S和5S rRNA转录物的合成。相比之下，4S tRNA和21S线粒体rRNA的合成并未受到广泛的抑制。在添加氯霉素之前添加60 microM血红素可部分保护其免受RNA合成的抑制。这些数据表明，在四膜虫中，核定向rRNA的持续合成与线粒体蛋白的合成有关。

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《Molecular and Cellular Biology》 |1982年第5期|共9页
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L Ruben; A B Hooper;
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中图分类细胞生物学;
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1. Inhibition of Neurospora crassa and yeast mitochondrial protein synthesis by ricin, a toxic protein inactive on E. coli protein synthesis [J] . Dirheimer Guy, Kuuml, ntzel Hans, FEBS Letters . 1976,第2期

机译：蓖麻毒素是一种对大肠杆菌蛋白质合成没有活性的有毒蛋白质，可抑制神经孢菌和酵母线粒体蛋白质的合成
2. Protein synthesis by brain-cortex mitochondria. Characterization of a 55S mitochondrial ribosome as the functional unit in protein synthesis by cortex mitochondria and its distinction from a contaminant cytoplasmic protein-synthesizing system [J] . A. Hernandez, I. Burdett, T. S. Work The biochemical journal . 1971,第2期

机译：大脑皮质线粒体的蛋白质合成。 55S线粒体核糖体作为皮层线粒体蛋白质合成中的功能单元的表征及其与污染物胞质蛋白质合成系统的区别
3. Evidence for a Competitive‐Displacement Model for the initiation of protein synthesis involving the intermolecular hybridization of 5 S rRNA, 18 S rRNA and mRNA [J] . Maxwell E.Stuart, Sarge Kevin D. FEBS Letters . 1991,第3期

机译：用于蛋白质合成的竞争置换模型的证据，涉及5 S rRNA，18 S rRNA和mRNA的分子间杂交
4. ~2H-metabolic labeling approach reveals reduced synthesis of hepatic mitochondrial proteins in a mouse model of NASH [C] . Kwangwon Lee, Abdullah Osme, Ling Li, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

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5. Characterization of pleiotropic pet mutants defective in regulation of mitochondrial respiration and mitochondrial protein synthesis. [D] . Jin, Can. 2001

机译：表征多效性宠物突变体在调节线粒体呼吸和线粒体蛋白质合成方面存在缺陷。
6. Dependence of nucleus-directed rRNA synthesis upon mitochondrial protein synthesis in Tetrahymena. [O] . L Ruben, A B Hooper 1982

机译：四膜虫中核定向rRNA合成对线粒体蛋白质合成的依赖性。
7. Dependence of nucleus-directed rRNA synthesis upon mitochondrial protein synthesis in Tetrahymena. [O] . Ruben, L, Hooper, A B 1982

机译：四膜虫中核定向rRNA合成对线粒体蛋白质合成的依赖性。

Dependence of nucleus-directed rRNA synthesis upon mitochondrial protein synthesis in Tetrahymena.

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