Immunoglobulin gene rearrangements in normal mouse B cells.

P Early; C Nottenburg; I Weissman; L Hood

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Immunoglobulin gene rearrangements in normal mouse B cells.

机译：正常小鼠B细胞中的免疫球蛋白基因重排。

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We have analyzed the structure of rearranged mu heavy-chain genes obtained from the genomic DNA of normal BALB/c mouse spleen cells expressing surface immunoglobulin M. Examples were found of two types of nonproductive rearrangements, which may be responsible for allelic exclusion in normal B cells. In one of these rearrangements, a germ line D gene segment has joined to the JH4 gene segment but no V/D joining has occurred. We present evidence that D gene segments lie as a cluster between V and J gene segments in the germ line. A comparison of conserved sequences in V and D gene segments suggests that the D gene segments, which are found only in the heavy-chain gene family, may have evolved from V gene segments similar to the Vk family.

机译：我们已经分析了从表达表面免疫球蛋白M的正常BALB / c小鼠脾细胞的基因组DNA获得的重排mu重链基因的结构。发现了两种非生产性重排的例子，这可能是正常B中等位基因排斥的原因细胞。在这些重排之一中，种系D基因片段已与JH4基因片段连接，但未发生V / D连接。我们目前的证据，D基因段位于生殖系中的V和J基因段之间的群集。比较V和D基因区段中的保守序列，表明仅在重链基因家族中发现的D基因区段可能已经从类似于Vk家族的V基因区段进化而来。

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《Molecular and Cellular Biology》 |1982年第7期|共8页
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P Early; C Nottenburg; I Weissman; L Hood;
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中图分类细胞生物学;
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1. Systematic design and testing of nested (RT-)PCR primers for specific amplification of mouse rearranged/expressed immunoglobulin variable region genes from small number of B cells. [J] . Rohatgi S, Ganju P, Sehgal D Journal of Immunological Methods . 2008,第2期

机译：嵌套（RT-）PCR引物的系统设计和测试，用于从少量B细胞中特异性扩增小鼠重排/表达的免疫球蛋白可变区基因。
2. T-cell receptor and immunoglobulin genes are rearranged together in Abelson virus-transformed pre-B and pre-T cells. [J] . W D Cook, A M Balaton Molecular and Cellular Biology . 1987,第1期

机译：T细胞受体和免疫球蛋白基因在Abelson病毒转化的pre-B和pre-T细胞中一起重新排列。
3. Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes. [J] . J Stavnezer, S Sirlin, J Abbott The Journal of Experomental Medicine . 1985,第3期

机译：在培养的I.29 B淋巴瘤细胞中诱导免疫球蛋白同种型转换。重链基因的伴随重排的表征。
4. Overexpression and Unique Rearrangement of VH2Transcripts in Immunoglobulin Variable Heavy ChainGenes in Ankylosing Spondylitis Patients [C] . Yeon Joo Kim, Nayoung Kim, Min-Kyung Lee, EU-Korea Conference on Science and Technology . 2011

机译：在强调脊柱胸腺炎患者中免疫球蛋白可变重的vh2transcript的过度表达和独特重新排列
5. MOUSE IMMUNOGLOBULIN HEAVY CHAIN GENE ORGANIZATION AND REARRANGEMENT: GENETIC BASES FOR ANTIBODY DIVERSITY AND REGULATED EXPRESSION [D] . EARLY, PHILIP WARREN. 1980

机译：小鼠免疫球蛋白重链基因的组织和重排：抗体多样性和调控表达的遗传基础
6. Immunoglobulin gene rearrangements in normal mouse B cells. [O] . P Early, C Nottenburg, I Weissman, 1982

机译：正常小鼠B细胞中的免疫球蛋白基因重排。
7. Immunoglobulin gene rearrangements in normal mouse B cells. [O] . Early, P, Nottenburg, C, Weissman, I, 1982

机译：正常小鼠B细胞中的免疫球蛋白基因重排。

Immunoglobulin gene rearrangements in normal mouse B cells.

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