Increased phosphorylation of tyrosine in vinculin does not occur upon transformation by some avian sarcoma viruses.

A M Antler; M E Greenberg; G M Edelman; H Hanafusa

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Increased phosphorylation of tyrosine in vinculin does not occur upon transformation by some avian sarcoma viruses.

机译：在一些禽肉瘤病毒转化后，纽蛋白中酪氨酸的磷酸化不会增加。

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The level of phosphotyrosine in vinculin was determined in chicken embryo fibroblasts transformed by various strains of avian sarcoma virus. As previously reported (Sefton et al., Cell 24:165-174, 1981), vinculin was phosphorylated at tyrosine residues in most cultures examined, but the level varied greatly and no detectable change was found in cultures infected with Fujinami sarcoma virus or UR2 sarcoma virus. Regardless of the level of vinculin phosphorylation, the number of organized microfilament bundles was found to be decreased in all transformed cells. These results strongly suggest that tyrosine phosphorylation of vinculin is not an obligatory step in cell transformation by this class of oncogenes, nor is it correlated with the associated cytoskeletal disarray.

机译：测定了由各种禽肉瘤病毒株转化的鸡胚成纤维细胞中纽蛋白中磷酸酪氨酸的水平。如先前的报道（Sefton等，Cell 24：165-174，1981），在大多数检查的培养物中酪蛋白残基上的磷酸蛋白链磷酸化，但水平变化很大，在感染了藤纳米肉瘤病毒或UR2的培养物中未发现可检测到的变化肉瘤病毒。不管链蛋白磷酸化的水平如何，在所有转化的细胞中发现有组织的微丝束的数量都减少了。这些结果有力地表明，这类致癌基因的新蛋白酪氨酸磷酸化不是细胞转化的必不可少的步骤，也不与相关的细胞骨架紊乱相关。

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《Molecular and Cellular Biology》 |1985年第1期|共5页
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A M Antler; M E Greenberg; G M Edelman; H Hanafusa;
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中图分类细胞生物学;
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1. Membrane association of a 36,000-dalton substrate for tyrosine phosphorylation in chicken embryo fibroblasts transformed by avian sarcoma viruses. [J] . K Radke, V C Carter, P Moss, Journal of cell biology . 1983,第5期

机译：禽肉瘤病毒转化的鸡胚成纤维细胞中酪氨酸磷酸化的36,000道尔顿底物的膜缔合。
2. Increased phosphorylation of vinculin on tyrosine does not occur during the release of stress fibers before mitosis in normal cells. [J] . M J Rosok, L R Rohrschneider Molecular and Cellular Biology . 1983,第3期

机译：在正常细胞的有丝分裂之前释放应力纤维期间，酪氨酸上的纽扣蛋白磷酸化没有增加。
3. Increased phosphorylation of vinculin on tyrosine does not occur during the release of stress fibers before mitosis in normal cells. [J] . M J Rosok, L R Rohrschneider Molecular and Cellular Biology . 1983,第3期

机译：在正常细胞的有丝分裂之前释放应力纤维期间，酪氨酸上的纽扣蛋白磷酸化没有增加。
4. TYROSINE NITRATION IN BLOOD VESSELS OCCURS WITH INCREASING NITRIC OXIDE CONCENTRATION: IMPLICATIONS FOR NITROVASODILATOR THERAPY [C] . C. Amirmansour, P. Vallance, R.G. Bogle NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling . 1999

机译：血管中的酪氨酸硝化随着一氧化氮浓度的增加而发生：对硝烯酶调节剂治疗的影响
5. Overexpression of the receptor tyrosine kinase EphA2 induces malignant transformation of benign mammary epithelia: Implication for increased cell survival and altered cellular adhesions in breast cancer. [D] . Zelinski, Daniel Paul. 2001

机译：受体酪氨酸激酶EphA2的过表达诱导了良性乳腺上皮的恶性转化：暗示增加细胞存活率和改变乳腺癌细胞粘附。
6. Increased phosphorylation of tyrosine in vinculin does not occur upon transformation by some avian sarcoma viruses. [O] . A M Antler, M E Greenberg, G M Edelman, 1985

机译：经一些禽肉瘤病毒转化后新蛋白中酪氨酸磷酸化的增加不会发生。
7. Increased phosphorylation of tyrosine in vinculin does not occur upon transformation by some avian sarcoma viruses. [O] . Antler, A M, Greenberg, M E, Edelman, G M, 1985

机译：经一些禽肉瘤病毒转化后，新蛋白中酪氨酸磷酸化的增加不会发生。
8. Increases in Tyrosine Phosphorylation Are Detectable Before Phospholipase C Activation after T Cell Receptor Stimulation. [R] . June, C. H., Fletcher, M. C., Ledbetter, J. A., 1990

机译：在T细胞受体刺激后，磷脂酶C激活前可检测到酪氨酸磷酸化的增加。

Increased phosphorylation of tyrosine in vinculin does not occur upon transformation by some avian sarcoma viruses.

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