Saccharomyces cerevisiae positive regulatory gene PET111 encodes a mitochondrial protein that is translated from an mRNA with a long 5' leader.

C A Strick; T D Fox

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Saccharomyces cerevisiae positive regulatory gene PET111 encodes a mitochondrial protein that is translated from an mRNA with a long 5' leader.

机译：酿酒酵母阳性调控基因PET111编码线粒体蛋白质，该蛋白质是从具有5'长前导序列的mRNA翻译而来的。

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The yeast nuclear gene PET111 is required specifically for translation of the mitochondrion-coded mRNA for cytochrome c oxidase subunit II. We have determined the nucleotide sequence of a 3-kilobase segment of DNA that carries PET111. The sequence contains a single long open reading frame that predicts a basic protein of 718 amino acids. The PET111 gene product is a mitochondrial protein, since a hybrid protein which includes the amino-terminal 154 amino acids of PET111 fused to beta-galactosidase is specifically associated with mitochondria. PET111 is translated from a 2.9-kilobase mRNA which, interestingly, has an extended 5'-leader sequence containing four short open reading frames upstream of the long open reading frame. These open reading frames exhibit an interesting pattern of overlap with each other and with the PET111 reading frame.

机译：酵母核基因PET111是细胞色素c氧化酶亚基II的线粒体编码mRNA的翻译所特有的。我们已经确定了携带PET111的3碱基碱基的DNA核苷酸序列。该序列包含一个长的开放阅读框，该框预测一个718个氨基酸的碱性蛋白质。 PET111基因产物是线粒体蛋白，因为包含与β-半乳糖苷酶融合的PET111的氨基末端154个氨基酸的杂合蛋白与线粒体特异性结合。 PET111从2.9碱基碱基的mRNA翻译而来，有趣的是，该碱基具有5'-leader延伸序列，在长开放阅读框的上游包含四个短开放阅读框。这些开放式阅读框彼此和与PET111阅读框呈现出有趣的重叠模式。

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《Molecular and Cellular Biology》 |1987年第8期|共7页
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C A Strick; T D Fox;
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1. PET111, a Saccharomyces cerevisiae Nuclear Gene Required for Translation of the Mitochondrial mRNA Encoding Cytochrome c Oxidase Subunit II [J] . Candace G. Poutre, Thomas D. Fox Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 1987,第4期

机译：PET111，啤酒酵母的核基因，用于翻译编码细胞色素c氧化酶亚基II的线粒体mRNA
2. PET111 acts in the 5'-leader of the Saccharomyces cerevisiae mitochondrial COX2 mRNA to promote its translation. [J] . J J Mulero, T D Fox Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 1993,第3期

机译：PET111在酿酒酵母线粒体COX2 mRNA的5'端中起作用，以促进其翻译。
3. Alteration of the Saccharomyces cerevisiae COX2 mRNA 5'-untranslated leader by mitochondrial gene replacement and functional interaction with the translational activator protein PET111. [J] . J J Mulero, T D Fox Molecular biology of the cell . 1993,第12期

机译：通过线粒体基因置换和与翻译激活蛋白PET111的功能相互作用，来改变酿酒酵母COX2 mRNA 5'-非翻译前导序列。
4. Detecting Protein-Domains DNA-Motifs Association in Saccharomyces cerevisiae Regulatory Networks [C] . Malhis, Nawar, Zhang, . 2007

机译：在酿酒酵母调控网络中检测蛋白质-域DNA-基序关联
5. RSF1 and RSF2, nuclear genes encoding proteins required for respiratory growth and mitochondrial DNA maintenance in Saccharomyces cerevisiae. [D] . Lu, Lin. 2003

机译：RSF1和RSF2是编码酿酒酵母中呼吸生长和线粒体DNA维持所需的蛋白质的核基因。
6. Saccharomyces cerevisiae positive regulatory gene PET111 encodes a mitochondrial protein that is translated from an mRNA with a long 5 leader. [O] . C A Strick, T D Fox 1987

机译：酿酒酵母阳性调控基因PET111编码线粒体蛋白质该蛋白质是从具有5长前导序列的mRNA翻译而来的。
7. Saccharomyces cerevisiae positive regulatory gene PET111 encodes a mitochondrial protein that is translated from an mRNA with a long 5' leader. [O] . Strick, C A, Fox, T D 1987

机译：酿酒酵母阳性调控基因PET111编码线粒体蛋白质，该蛋白质是从具有5'长前导序列的mRNA翻译而来的。

Saccharomyces cerevisiae positive regulatory gene PET111 encodes a mitochondrial protein that is translated from an mRNA with a long 5' leader.

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