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首页> 外文期刊>Molecular and Cellular Biology >Signal for DNA methylation associated with tandem duplication in Neurospora crassa.
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Signal for DNA methylation associated with tandem duplication in Neurospora crassa.

机译：与神经孢菌中串联重复相关的DNA甲基化信号。

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摘要

Most cytosine residues are subject to methylation in the zeta-eta (zeta-eta) region of Neurospora crassa. The region consists of a tandem direct duplication of a 0.8-kilobase-pair element including a 5S rRNA gene. The repeated elements have diverged about 15% by the occurrence of numerous CG to TA mutations, which probably resulted from deamination of methylated cytosines. Most but not all common laboratory strains of N. crassa have methylated duplicated DNA at the zeta-eta locus. However, many strains of N. crassa and strains of N. tetrasperma, N. sitophila, and N. intermedia have one instead of two copies of the homologous DNA and it is not methylated. A cross of strains differing at the zeta-eta locus produced progeny which all had duplicated, methylated, or unique, unmethylated DNA, like the parental strains. We conclude that a signal causing unprecedented heavy DNA methylation is present in the zeta-eta region.
机译：大多数胞嘧啶残基在神经孢霉的zeta-eta（zeta-eta）区域内发生甲基化。该区域由包含5S rRNA基因的0.8碱基对直接串联直接重复组成。由于发生大量的CG到TA突变，重复的元素相差约15％，这可能是由于甲基化的胞嘧啶脱氨基所致。大多数但不是全部常见的克雷萨氏菌实验室菌株在zeta-eta位点处甲基化了重复的DNA。但是，许多猪笼草菌株和四精子猪笼草，嗜盐猪笼草和中间猪笼草的菌株具有一个而不是两个拷贝的同源DNA，并且没有被甲基化。在zeta-eta基因座处不同的菌株杂交产生了后代，就像亲本菌株一样，它们都具有重复的，甲基化的或独特的未甲基化的DNA。我们得出结论，在zeta-eta区中存在导致空前的重DNA甲基化的信号。

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