P21 v-ras inhibits induction of c-myc and c-fos expression by platelet-derived growth factor.

J N Zullo; D V Faller

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P21 v-ras inhibits induction of c-myc and c-fos expression by platelet-derived growth factor.

机译：P21 v-ras抑制血小板衍生生长因子诱导c-myc和c-fos表达。

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The viral oncogene v-ras inhibited the platelet-derived growth factor (PDGF)-induced upregulation of c-myc and c-fos proto-oncogene expression in fibroblast monolayers. These v-ras-containing cells proliferated in the absence of c-myc induction and no longer required PDGF to support growth. Fibroblasts expressing v-ras continued to express the same number of functional PDGF receptors on their surface as uninfected cells, yet the usual induction of transcription of the genes c-myc, c-fos, and JE in response to PDGF stimulation did not occur in the presence of newly introduced v-ras or chronic v-ras gene expression, and synthesis of c-myc protein did not occur. This inhibitory effect on growth factor-mediated induction of cellular proto-oncogenes was specific for PDGF in that induction of the c-myc and c-fos genes by certain other factors was not impaired.

机译：病毒癌基因v-ras抑制了血小板衍生生长因子（PDGF）诱导的成纤维细胞单层c-myc和c-fos原癌基因表达上调。这些不含v-ras的细胞在不存在c-myc诱导的情况下增殖，不再需要PDGF支持生长。表达v-ras的成纤维细胞继续在其表面上表达与未感染细胞相同数量的功能性PDGF受体，但是在2000年，并未发生响应于PDGF刺激而通常诱导的基因c-myc，c-fos和JE转录。新引入的v-ras或慢性v-ras基因表达的存在以及c-myc蛋白的合成均未发生。这种对生长因子介导的细胞原癌基因诱导的抑制作用对PDGF是特异性的，因为某些其他因子对c-myc和c-fos基因的诱导不会受到损害。

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《Molecular and Cellular Biology》 |1988年第12期|共6页
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J N Zullo; D V Faller;
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中图分类细胞生物学;
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2. Progestins both stimulate and inhibit breast cancer cell cycle progression while increasing expression of transforming growth factor alpha, epidermal growth factor receptor, c-fos, and c-myc genes. [J] . E A Musgrove, C S Lee, R L Sutherland Molecular and Cellular Biology . 1991,第10期

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5. Regulation of vascular smooth muscle cell signaling and metabolism by platelet-derived growth factor. [D] . Perez, Jessica. 2010

机译：血小板衍生生长因子对血管平滑肌细胞信号传导和代谢的调节。
6. P21 v-ras inhibits induction of c-myc and c-fos expression by platelet-derived growth factor. [O] . J N Zullo, D V Faller 1988

机译：P21 v-ras抑制血小板衍生生长因子诱导c-myc和c-fos表达。
7. P21 v-ras inhibits induction of c-myc and c-fos expression by platelet-derived growth factor. [O] . Zullo, J N, Faller, D V 1988

机译：P21 v-ras抑制血小板衍生生长因子诱导c-myc和c-fos表达。

P21 v-ras inhibits induction of c-myc and c-fos expression by platelet-derived growth factor.

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