Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family.

A Himmler

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Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family.

机译：牛tau基因的结构：选择性剪接的转录本可产生蛋白质家族。

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Tau, a major class of microtubule-associated proteins, consists of a family of proteins that are heterogeneous in molecular weight. The presence of internal deletions in previously described cDNA clones for murine and bovine tau suggested that alternative splicing of transcripts could account for the protein size heterogeneity. Analysis of the exon-intron structure of the bovine tau gene provided sequence information necessary to detect new variants of tau transcripts by in vitro amplification techniques. The variant transcripts found corresponded to mRNA species missing one or more exons, which suggested that by skipping various exons during mRNA splicing, a family of proteins is generated. Four major tau protein isoforms isolated from bovine brain were identified by comparison with translation products of cDNA constructs and the use of antisera raised against synthetic peptides. These studies provide reagents and a basis for analyzing potentially altered forms of tau proteins in brains of patients with Alzheimer's disease.

机译：Tau是与微管相关的蛋白质的主要类别，由分子量不同的蛋白质家族组成。先前描述的鼠和牛tau蛋白cDNA克隆内部缺失的存在提示，转录本的可变剪接可以解释蛋白质大小的异质性。牛tau基因外显子-内含子结构的分析提供了通过体外扩增技术检测tau转录本的新变体所必需的序列信息。发现的变异转录物对应于缺失一个或多个外显子的mRNA种类，这表明通过在mRNA剪接过程中跳过各种外显子，可以生成蛋白质家族。通过与cDNA构建体的翻译产物进行比较，并使用针对合成肽的抗血清，鉴定了从牛脑中分离出的四种主要的tau蛋白同工型。这些研究为分析阿尔茨海默氏病患者大脑中tau蛋白的潜在变化形式提供了试剂和基础。

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《Molecular and Cellular Biology》 |1989年第4期|共8页
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A Himmler;
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中图分类细胞生物学;
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1. Two transcripts are generated from the pancreatitis associated protein II gene by alternative splicing in the 5′ untranslated region [J] . Sophie Vasseur, Jean-Marc Frigerio, Nelson Javier Dusetti, Biochimica et biophysica acta. Gene structure and expression . 1995,第2期

机译：通过在5'非翻译区进行选择性剪接，从胰腺炎相关蛋白II基因产生两个转录本
2. A novel pathway for alternative splicing: identification of an RNA intermediate that generates an alternative 5' splice donor site not present in the primary transcript of AMPD1. [J] . I Mineo, P R Clarke, R L Sabina, Molecular and Cellular Biology . 1990,第10期

机译：替代剪接的新途径：鉴定产生AMPD1初级转录物中不存在的替代5'剪接供体位点的RNA中间体。
3. Genomic organization and structure of the 5'-flanking region of the TEX101 gene: alternative promoter usage and splicing generate transcript variants with distinct 5'-untranslated region. [J] . Tsukamoto H, Takizawa T, Takamori K, Molecular reproduction and development . 2007,第2期

机译：TEX101基因5'侧翼区的基因组组织和结构：替代启动子的使用和剪接产生具有独特5'-非翻译区的转录变体。
4. Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes [C] . Richard E. Green, Benjamin P. Lewis, R. Tyler Hillman, International Conference on Intelligent Systems for Molecular biology . 2003

机译：普遍预测的无意义介导的mRNA衰减的人正常和疾病基因的替代剪接转录物
5. Alternative splice sites and transcript variations of CACNA1H---A human T-calcium channel gene candidate for idiopathic generalized epilepsies. [D] . Zhong, Xiaoli. 2008

机译：CACNA1H的其他剪接位点和转录本变异-特发性广义癫痫的人类T钙通道基因候选者。
6. Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family. [O] . A Himmler 1989

机译：牛tau基因的结构：选择性剪接的转录本可生成蛋白质家族。
7. Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family. [O] . Himmler, A 1989

机译：牛tau基因的结构：选择性剪接的转录本可生成蛋白质家族。

Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family.

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