Synergy between the NF-E1 erythroid-specific transcription factor and the CACCC factor in the erythroid-specific promoter of the human porphobilinogen deaminase gene.

J Frampton; M Walker; M Plumb; P R Harrison

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Synergy between the NF-E1 erythroid-specific transcription factor and the CACCC factor in the erythroid-specific promoter of the human porphobilinogen deaminase gene.

机译：人卟啉胆原原脱氨酶基因的红系特异性启动子中的NF-E1红系特异性转录因子和CACCC因子之间的协同作用。

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A 114-base-pair promoter fragment of the human porphobilinogen deaminase gene functioned in an erythroid-specific manner in transient transfection experiments. Site-directed mutagenesis of the binding site for the erythroid-specific transcription factor (NF-E1) or an adjacent CACCC motif abolished the promoter activity. Increasing the spacing between these sites progressively reduced promoter activity, but there was no evidence that a critical alignment of the two factors on the DNA helix was required.

机译：在短暂的转染实验中，人血胆色素原脱氨酶基因的114个碱基对的启动子片段以类红细胞特异性的方式起作用。红细胞特异性转录因子（NF-E1）或相邻的CACCC基序的结合位点的定点诱变消除了启动子的活性。增加这些位点之间的间隔会逐渐降低启动子活性，但是没有证据表明需要对DNA螺旋上的两个因子进行严格的比对。

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《Molecular and Cellular Biology》 |1990年第7期|共5页
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J Frampton; M Walker; M Plumb; P R Harrison;
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中图分类细胞生物学;
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1. The rat #beta#~miny_b-globin promoter: nuclear protein factors and erythroid-specific induction of transcription [J] . S. Pavlovic, T. Mitrovic, G. Nikcevic, Cellular and molecular life sciences: CMLS . 1999,第9a10期

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6. Synergy between the NF-E1 erythroid-specific transcription factor and the CACCC factor in the erythroid-specific promoter of the human porphobilinogen deaminase gene. [O] . J Frampton, M Walker, M Plumb, 1990

机译：人卟啉胆碱原脱氨酶基因的红系特异性启动子中的NF-E1红系特异性转录因子和CACCC因子之间的协同作用。
7. Synergy between the NF-E1 erythroid-specific transcription factor and the CACCC factor in the erythroid-specific promoter of the human porphobilinogen deaminase gene. [O] . Frampton, J, Walker, M, Plumb, M, 1990

机译：人卟啉胆碱原脱氨酶基因的红系特异性启动子中的NF-E1红系特异性转录因子和CACCC因子之间的协同作用。

Synergy between the NF-E1 erythroid-specific transcription factor and the CACCC factor in the erythroid-specific promoter of the human porphobilinogen deaminase gene.

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