An intergenic G-rich region in Leishmania tarentolae kinetoplast maxicircle DNA is a pan-edited cryptogene encoding ribosomal protein S12.

D A Maslov; N R Sturm; B M Niner; E S Gruszynski; M Peris; L Simpson

首页> 外文期刊>Molecular and Cellular Biology >An intergenic G-rich region in Leishmania tarentolae kinetoplast maxicircle DNA is a pan-edited cryptogene encoding ribosomal protein S12.

【24h】

An intergenic G-rich region in Leishmania tarentolae kinetoplast maxicircle DNA is a pan-edited cryptogene encoding ribosomal protein S12.

机译：塔氏Leishmania tarentolae动植物最大圆环DNA中的一个富含基因的G区是编码核糖体蛋白S12的泛编辑密码基因。

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Six short G-rich intergenic regions in the maxicircle of Leishmania tarentolae are conserved in location and polarity in two other kinetoplastid species. We show here that G-rich region 6 (G6) represents a pan-edited cryptogene which contains at least two domains edited independently in a 3'-to-5' manner connected by short unedited regions. In the completely edited RNA, 117 uridines are added at 49 sites and 32 uridines are deleted at 13 sites, creating a translated 85-amino-acid polypeptide. Similar polypeptides are probably encoded by pan-edited G6 transcripts in two other species. The G6 polypeptide has significant sequence similarity to the family of S12 ribosomal proteins. A minicircle-encoded gRNA overlaps 12 editing sites in G6 mRNA, and chimeric gRNA/mRNA molecules were shown to exist, in agreement with the transesterification model for editing.

机译：在其他两个动体体物种中，塔氏Leishmania tarentolae的最大圆上有六个短的富含G的基因间区域，在位置和极性上都是保守的。我们在这里显示，富含G的区域6（G6）代表一个泛编辑的密码基因，其中包含至少两个通过短的未编辑区域连接的以3'至5'方式独立编辑的域。在完全编辑的RNA中，在49个位点添加了117个尿苷，在13个位点删除了32个尿苷，生成了一个翻译的85个氨基酸的多肽。相似的多肽可能由另外两个物种中的经过全面编辑的G6转录本编码。 G6多肽与S12核糖体蛋白家族具有明显的序列相似性。一个小圆圈编码的gRNA与G6 mRNA中的12个编辑位点重叠，并且显示存在嵌合gRNA / mRNA分子，这与用于酯交换的模型一致。

著录项

来源
《Molecular and Cellular Biology》 |1992年第1期|共12页
作者
D A Maslov; N R Sturm; B M Niner; E S Gruszynski; M Peris; L Simpson;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类细胞生物学;
关键词

相似文献

外文文献
中文文献
专利

1. The divergent region of the Leishmania tarentolae kinetoplast maxicircle DNA contains a diverse set of repetitive sequences [J] . Larry Simpson, Michael L. Muhich, Nicolas Neckelmann Nucleic acids research . 1985,第9期

机译：利什曼原虫tarentolae动植物最大圆环DNA的发散区包含各种重复序列
2. Mapping and 5′ end determination of kinetoplast maxicircle gene transcripts from Leishmania tarentolae [J] . Agda M. Simpson, Larry Simpson, Michael L. Muhich, Nucleic acids research . 1985,第16期

机译：塔氏Leishmania tarentolae的运动体最大圆基因转录产物的定位及5'端测定
3. U-insertion/deletion RNA editing multiprotein complexes and mitochondrial ribosomes in Leishmania tarentolae are located in antipodal nodes adjacent to the kinetoplast DNA [J] . Wong Richard G., Kazane Katelynn, Maslov Dmitri A., Mitochondrion . 2015,第Null期

机译：塔氏疟原虫中的U插入/缺失RNA编辑多蛋白复合物和线粒体核糖体位于与动子体DNA相邻的对映结点中
4. Site-specific DNA replication fork arrest within the ribosomal DNA intergenic spacer regions of Schizosaccharomyces pombe [D] . Krings, Gregor 2008

机译：定点DNA复制叉停在粟酒裂殖酵母核糖体DNA基因间隔区中
5. An intergenic G-rich region in Leishmania tarentolae kinetoplast maxicircle DNA is a pan-edited cryptogene encoding ribosomal protein S12. [O] . D A Maslov, N R Sturm, B M Niner, 1992

机译：塔氏Leishmania tarentolae动植物最大圆环DNA中一个富含基因的G区是编码核糖体蛋白S12的泛编辑密码基因。
6. An intergenic G-rich region in Leishmania tarentolae kinetoplast maxicircle DNA is a pan-edited cryptogene encoding ribosomal protein S12. [O] . Maslov, D A, Sturm, N R, Niner, B M, 1992

机译：塔氏Leishmania tarentolae动植物最大圆环DNA中的一个富含基因的G区是编码核糖体蛋白S12的泛编辑密码基因。

An intergenic G-rich region in Leishmania tarentolae kinetoplast maxicircle DNA is a pan-edited cryptogene encoding ribosomal protein S12.

摘要

著录项

相似文献

相关主题

期刊订阅