The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase.

M Shirayama; Y Matsui; A Toh-E

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The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase.

机译：编码GTP结合蛋白的酵母TEM1基因参与M期的终止。

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LTE1 belongs to the CDC25 family that encodes a guanine nucleotide exchange factor for GTP-binding proteins of the ras family. Previously we have shown that LTE1 is essential for termination of M phase at low temperatures. We have identified TEM1 as a gene that, when present on a multicopy plasmid, suppresses the cold-sensitive phenotype of lte1. Sequence analysis of TEM1 and GTP-binding analysis of the gene product revealed that TEM1 encodes a novel low-molecular-weight GTP-binding protein. The defect of TEM1 was lethal, and the tem1-defective cells were arrested at telophase with high H1-kinase activity under restrictive conditions, indicating that TEM1 is required to exit from M phase. The defect of TEM1 was suppressed by a high dose of CDC15, which encodes a protein kinase homologous to mitogen-activated protein kinase kinase kinases. The genetic interaction among LTE1, TEM1, and CDC15 indicates that they cooperatively play an essential role for termination of M phase.

机译：LTE1属于CDC25家族，该家族编码ras家族GTP结合蛋白的鸟嘌呤核苷酸交换因子。之前我们已经证明LTE1对于在低温下终止M相至关重要。我们已经确定TEM1是一个基因，当存在于多拷贝质粒上时，它可以抑制lte1的冷敏感表型。 TEM1的序列分析和基因产物的GTP结合分析表明，TEM1编码一种新型的低分子量GTP结合蛋白。 TEM1的缺陷是致死性的，并且在限制性条件下，具有高H1激酶活性的tem1缺陷细胞被停滞在末期，表明TEM1需要从M期退出。高剂量的CDC15可抑制TEM1的缺陷，该CDC15编码的蛋白激酶与促分裂原活化的蛋白激酶激酶激酶同源。 LTE1，TEM1和CDC15之间的遗传相互作用表明，它们在M相终止中起着协同作用。

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《Molecular and Cellular Biology》 |1994年第11期|共7页
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M Shirayama; Y Matsui; A Toh-E;
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中图分类细胞生物学;
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1. Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity. [J] . M Ziman, J M OBrien, L A Ouellette, Molecular and Cellular Biology . 1991,第7期

机译：CDC42Sc（一种酿酒酵母基因）的突变分析，该基因编码与细胞极性控制有关的假定的GTP结合蛋白。
2. lingerer, a Drosophila Gene Involved in Initiation and Termination of Copulation, Encodes a Set of Novel Cytoplasmic Proteins [J] . Daisuke Yamamoto, Hisato Kuniyoshi, Kotaro Baba, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2002,第4期

机译：lingerer，果蝇基因参与启动和终止的交配，编码一组新型的细胞质蛋白。
3. ISOLATION OF AN ADDITIONAL SOYBEAN CDNA ENCODING YPT/RAB-RELATED SMALL GTP-BINDING PROTEIN AND ITS FUNCTIONAL COMPARISON TO SYPT USING A YEAST YPT1-1 MUTANT [J] . Kim WY., Lee DC., Lee KO., Plant Molecular Biology . 1996,第4期

机译：编码YPT / RAB相关小GTP结合蛋白的大豆CDNA的分离及其酵母YPT1-1突变体的功能比较
4. Development of Yeast Platform for the Expression of Membrane Proteins Involved in Various Biological Processes [C] . Kajal Arora, Prabuddha K. Kundu, Nupur Mehrotra PEGS . 2015

机译：酵母平台的发展，用于表达各种生物过程的膜蛋白
5. Structure and regulation of the gene encoding the alpha-subunit of GTP-binding regulatory protein Gz. [D] . Chang, Po-Yuan. 1996

机译：编码GTP结合调节蛋白Gz的alpha亚基的基因的结构和调控。
6. The yeast TEM1 gene which encodes a GTP-binding protein is involved in termination of M phase. [O] . M Shirayama, Y Matsui, A Toh-E 1994

机译：编码GTP结合蛋白的酵母TEM1基因参与M期的终止。
7. The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase. [O] . Shirayama, M, Matsui, Y, Toh-E, A 1994

机译：编码GTP结合蛋白的酵母TEM1基因参与M期的终止。
8. Transcriptional Regulation of Genes Encoding Proteins Involved in Peroxisome Biogenesis in Yeast [R] . Einerhand, A. W. C. 1992

机译：酵母中过氧化物酶体生物合成中蛋白质编码基因的转录调控

The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase.

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