Sgs-3 chromatin structure and trans-activators: developmental and ecdysone induction of a glue enhancer-binding factor, GEBF-I, in Drosophila larvae.

P Georgel; P Ramain; A Giangrande; G Dretzen; G Richards; M Bellard

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Sgs-3 chromatin structure and trans-activators: developmental and ecdysone induction of a glue enhancer-binding factor, GEBF-I, in Drosophila larvae.

机译：Sgs-3染色质结构和反式激活剂：果蝇幼虫中胶增强剂结合因子GEBF-1的发育诱导和蜕皮激素诱导。

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The transcription of the Drosophila melanogaster 68C salivary gland glue gene Sgs-3 involves the interaction of a distal and a proximal regulatory region. These are marked in vivo by a specific chromatin structure which is established sequentially during development, starting early in embryogenesis. The distal region is characterized by a stage- and tissue-specific DNase I hypersensitive site. A stage- and tissue-specific factor, GEBF-I, binds in this region and is missing in 2B5 mutant larvae which lack Sgs-3 transcripts. This binding involves the simultaneous interaction with two distinct DNA sequences which induces conformational changes in the protein. Salivary glands acquire competence to respond to ecdysone in the mid-third larval instar, whereafter the hormone rapidly induces both the GEBF-I protein and Sgs-3 transcription.

机译：果蝇68C唾液腺胶基因Sgs-3的转录涉及远端和近端调节区域的相互作用。这些在体内被特定的染色质结构标记，该结构在发育过程中从胚胎发生的早期开始就相继建立。远端区域的特征在于阶段和组织特异性的DNase I超敏位点。阶段和组织特异性因子GEBF-1在该区域结合，在缺少Sgs-3转录本的2B5突变幼虫中缺失。这种结合涉及与两个不同的DNA序列的同时相互作用，从而诱导蛋白质的构象变化。唾液腺在幼虫中龄期获得对蜕皮激素的反应能力，此后激素迅速诱导GEBF-1蛋白和Sgs-3转录。

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《Molecular and Cellular Biology》 |1991年第1期|共10页
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P Georgel; P Ramain; A Giangrande; G Dretzen; G Richards; M Bellard;
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中图分类细胞生物学;
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1. Drosophila glue gene Sgs-3: Sequences required for puffing and transcriptional regulation☆ [J] . Madeline A. Crosby, Elliot M. Meyerowitz Developmental biology . 1986,第2期

机译：果蝇胶基因Sgs-3：膨化和转录调控所需的序列☆
2. The steroid hormone ecdysone functions with intrinsic chromatin remodeling factors to control female germline stem cells in Drosophila. [J] . Ables ET, Drummond Barbosa D Cell stem cell . 2010,第5期

机译：类固醇激素蜕皮激素与内在的染色质重塑因子一起起作用，以控制果蝇中的雌性种系干细胞。
3. Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors [J] . Karine Narbonne-Reveau, Cédric Maurange PLoS Biology . 2019,第2期

机译：蜕皮激素通过双稳态ZBTB转录因子在果蝇中的发育调控
4. CCAAT/Enhancer-Binding Protein Beta Controls Differentiation-Specific Expression of Chromatin Remodeling Factor BRM [C] . Toshinari Itoh, Katsuhide Miyake, Shinji Iijima Annual Meeting of the Japanese Association for Animal Cell Technology . 2009

机译：CCAAT / Enhancer结合蛋白β控制染色质重塑因子BRM的分化特异性表达
5. A microRNA forms feedback loops with protein factors and provides robustness to developmental decisions in the Drosophila eye. [D] . Li, Xin. 2006

机译：microRNA与蛋白质因子形成反馈环，并为果蝇眼中的发育决定提供鲁棒性。
6. Sgs-3 chromatin structure and trans-activators: developmental and ecdysone induction of a glue enhancer-binding factor GEBF-I in Drosophila larvae. [O] . P Georgel, P Ramain, A Giangrande, 1991

机译：Sgs-3染色质结构和反式激活剂：果蝇幼虫中胶增强剂结合因子GEBF-1的发育诱导和蜕皮激素诱导。
7. Sgs-3 chromatin structure and trans-activators: developmental and ecdysone induction of a glue enhancer-binding factor, GEBF-I, in Drosophila larvae. [O] . Georgel, P, Ramain, P, Giangrande, A, 1991

机译：Sgs-3染色质结构和反式激活剂：果蝇幼虫中胶增强剂结合因子GEBF-1的发育诱导和蜕皮激素诱导。

Sgs-3 chromatin structure and trans-activators: developmental and ecdysone induction of a glue enhancer-binding factor, GEBF-I, in Drosophila larvae.

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