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首页> 外文期刊>Molecular and Cellular Biology >Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.
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Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.

机译：Can，可能是与髓样白血病发生有关的致癌基因，可以通过将其3'半部分融合到不同基因上来激活：设定基因的表征。

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The translocation (6;9)(p23;q34) in acute nonlymphocytic leukemia results in the formation of a highly consistent dek-can fusion gene. Translocation breakpoints invariably occur in single introns of dek and can, which were named icb-6 and icb-9, respectively. In a case of acute undifferentiated leukemia, a breakpoint was detected in icb-9 of can, whereas no breakpoint could be detected in dek. Genomic and cDNA cloning showed that instead of dek, a different gene was fused to can, which was named set. set encodes transcripts of 2.0 and 2.7 kb that result from the use of alternative polyadenylation sites. Both transcripts contain the open reading frame for a putative SET protein with a predicted molecular mass of 32 kDa. The set-can fusion gene is transcribed into a 5-kb transcript that contains a single open reading frame predicting a 155-kDa chimeric SET-CAN protein. The SET sequence shows homology with the yeast nucleosome assembly protein NAP-I. The only common sequence motif of SET and DEK proteins is an acidic region. SET has a long acidic tail, of which a large part is present in the predicted SET-CAN fusion protein. The set gene is located on chromosome 9q34, centromeric of c-abl. Since a dek-can fusion gene is present in t(6;9) acute myeloid leukemia and a set-can fusion gene was found in a case of acute undifferentiated leukemia, we assume that can may function as an oncogene activated by fusion of its 3' part to dek, set, or perhaps other genes.
机译：在急性非淋巴细胞性白血病中易位（6; 9）（p23; q34）导致形成高度一致的dek-can融合基因。易位断点总是出现在dek和can的单个内含子中，分别称为icb-6和icb-9。在急性未分化白血病的情况下，在罐头的icb-9中检测到断点，而在dek中未检测到断点。基因组和cDNA克隆显示，与dek融合的是罐子中的另一种基因，称为set。集编码由使用替代的聚腺苷酸化位点产生的2.0和2.7 kb的转录本。两种转录本均包含推定的SET蛋白的开放阅读框，其预测分子量为32 kDa。 Set-can融合基因被转录成一个5kb的转录本，该转录本包含一个预测155-kDa嵌合SET-CAN蛋白的开放阅读框。 SET序列显示出与酵母核小体组装蛋白NAP-1的同源性。 SET和DEK蛋白质的唯一常见序列基序是酸性区域。 SET具有长酸性尾巴，其中很大一部分存在于预测的SET-CAN融合蛋白中。设定的基因位于染色体9q34，c-abl的着丝粒。由于在t（6; 9）急性髓细胞性白血病中存在dek-can融合基因，而在急性未分化白血病的病例中发现了set-can融合基因，因此我们认为can可能是通过其融合而激活的癌基因3'部分是dek，set或其他基因。

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