• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular and Cellular Biology >Inactivation of YME1, a member of the ftsH-SEC18-PAS1-CDC48 family of putative ATPase-encoding genes, causes increased escape of DNA from mitochondria in Saccharomyces cerevisiae.
【24h】

Inactivation of YME1, a member of the ftsH-SEC18-PAS1-CDC48 family of putative ATPase-encoding genes, causes increased escape of DNA from mitochondria in Saccharomyces cerevisiae.

机译：YME1，ftsH-SEC18-PAS1-CDC48家族假定的ATPase编码基因的成员的失活导致酿酒酵母中DNA从线粒体逃逸的增加。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The yeast nuclear gene YME1 was one of six genes recently identified in a screen for mutations that elevate the rate at which DNA escapes from mitochondria and migrates to the nucleus. yme1 mutations, including a deletion, cause four known recessive phenotypes: an elevation in the rate at which copies of TRP1 and ARS1, integrated into the mitochondrial genome, escape to the nucleus; a heat-sensitive respiratory-growth defect; a cold-sensitive growth defect on rich glucose medium; and synthetic lethality in rho- (cytoplasmic petite) cells. The cloned YME1 gene complements all of these phenotypes. The gene product, Yme1p, is immunologically detectable as an 82-kDa protein present in mitochondria. Yme1p is a member of a family of homologous putative ATPases, including Sec18p, Pas1p, Cdc48p, TBP-1, and the FtsH protein. Yme1p is most similar to the Escherichia coli FtsH protein, an essential protein involved in septum formation during cell division. This observation suggests the hypothesis that Yme1p may play a role in mitochondrial fusion and/or division.
机译：酵母核基因YME1是最近在突变筛选中鉴定的六个基因之一，这些突变可提高DNA从线粒体逃逸并迁移到细胞核的速率。 yme1突变（包括缺失）引起四种已知的隐性表型：整合到线粒体基因组中的TRP1和ARS1拷贝逃逸到细胞核的速率增加;热敏呼吸生长缺陷;在富含葡萄糖的培养基上出现冷敏感的生长缺陷;和（细胞质小细胞）细胞的合成杀伤力。克隆的YME1基因与所有这些表型互补。 Yme1p基因产物可作为线粒体中存在的82 kDa蛋白进行免疫检测。 Yme1p是同源推定ATP酶家族的成员，包括Sec18p，Pas1p，Cdc48p，TBP-1和FtsH蛋白。 Yme1p与大肠杆菌FtsH蛋白最相似，后者是在细胞分裂过程中参与间隔形成的必需蛋白。该观察结果提出了Yme1p可能在线粒体融合和/或分裂中起作用的假设。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号