A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist.

J C Yin; J S Wallach; E L Wilder; J Klingensmith; D Dang; N Perrimon; H Zhou; T Tully; W G Quinn

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A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist.

机译：果蝇CREB / CREM同源物编码多种同工型，包括环状依赖AMP的蛋白激酶响应转录激活剂和拮抗剂。

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We have characterized a Drosophila gene that is a highly conserved homolog of the mammalian cyclic AMP (cAMP)-responsive transcription factors CREB and CREM. Uniquely among Drosophila genes characterized to date, it codes for a cAMP-responsive transcriptional activator. An alternatively spliced product of the same gene is a specific antagonist of cAMP-inducible transcription. Analysis of the splicing pattern of the gene suggests that the gene may be the predecessor of the mammalian CREB and CREM genes.

机译：我们已经表征了果蝇基因，它是哺乳动物环AMP（cAMP）响应转录因子CREB和CREM的高度保守的同源物。在迄今为止已表征的果蝇基因中，它独特地编码cAMP反应性转录激活因子。相同基因的另一种剪接产物是cAMP诱导型转录的特异性拮抗剂。基因剪接模式的分析表明，该基因可能是哺乳动物CREB和CREM基因的前身。

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《Molecular and Cellular Biology》 |1995年第9期|共8页
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J C Yin; J S Wallach; E L Wilder; J Klingensmith; D Dang; N Perrimon; H Zhou; T Tully; W G Quinn;
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中图分类细胞生物学;
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1. Expression of the cyclic AMP-dependent transcription factors, CREB, CREM and ATF2, in the human myometrium during pregnancy and labour. [J] . Bailey J, Sparey C, Phillips RJ, Molecular human reproduction. . 2000,第7期

机译：妊娠和分娩过程中，环AMP依赖性转录因子CREB，CREM和ATF2在人子宫内膜中的表达。
2. Role of basic region leucine zipper transcription factors cyclic AMP response element binding protein (CREB), CREB2, activating transcription factor 2 and CAAT/enhancer binding protein alpha in cyclic AMP response element-mediated transcription. [J] . Thiel G, Al Sarraj J, Vinson C, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2005,第2期

机译：碱性区域亮氨酸拉链转录因子环状AMP反应元件结合蛋白（CREB），CREB2，活化转录因子2和CAAT /增强子结合蛋白α在环状AMP反应元件介导的转录中的作用。
3. Transcriptional activation of phosphodiesterase 7B1 by dopamine D1 receptor stimulation through the cyclic AMP/cyclic AMP-dependent protein kinase/cyclic AMP-response element binding protein pathway in primary striatal neurons. [J] . Sasaki T, Kotera J, Omori K Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2004,第2期

机译：多巴胺D1受体刺激通过初级纹状体神经元中的环AMP /环AMP依赖蛋白激酶/环AMP响应元件结合蛋白途径刺激磷酸二酯酶7B1的转录激活。
4. CREB-binding Protein (CBP) p300 Enhanced the Expression of Cardiac Hypertrophy-Specific Genes Activated by Myocardin-Related Transcription Factor-A (MRTF-A) [C] . Li Mingzhe, Wang Zhenyu, Xie Zhongyi, Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on . 2012

机译：CREB结合蛋白（CBP）p300增强心肌相关转录因子-A（MRTF-A）激活的心肌肥大基因的表达。
5. Activating Transcription Factor 1 and cyclic AMP response element binding protein: Characterization and analysis of contributions to transformation. [D] . Bosilevac, Joseph M. 1998

机译：激活转录因子1和环状AMP反应元件结合蛋白：表征和分析对转化的贡献。
6. A Drosophila CREB/CREM homolog encodes multiple isoforms including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist. [O] . J C Yin, J S Wallach, E L Wilder, 1995

机译：果蝇CREB / CREM同源物编码多种同工型包括环状依赖AMP的蛋白激酶响应转录激活剂和拮抗剂。
7. A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist. [O] . Yin, J C, Wallach, J S, Wilder, E L, 1995

机译：果蝇CREB / CREM同源物编码多种同工型，包括环状依赖AMP的蛋白激酶响应转录激活剂和拮抗剂。

A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist.

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