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Location of 64K collagen producer chondrocytes in developing chicken embryo tibiae.

机译:发育中的鸡胚胫骨中64K胶原产生剂软骨细胞的位置。

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The synthesis of a new low-molecular-weight collagen by cultured chicken embryo chondrocytes has been recently demonstrated (Capasso et al., Exp. Cell Res. 142:197-206, 1982; Gibson et al., J. Cell Biol. 93:767-774, 1982; Schmid and Conrad, J. Biol. Chem. 257:12444-12450, 1982). In this paper we report results on the location of chondrocytes synthesizing this new collagen (64K collagen) in the developing chicken embryo. The 64K collagen is synthesized in very large amounts by cells concentrated at the diaphysis of 9-day-old and at the epiphysis of 17-day-old embryo tibiae. These regions are characterized by a remodeling of the cartilage matrix leading to the replacement of the cartilage with bone tissue; therefore, this collagen appears to be a marker of a specific developmental stage of chondrocytes. The origin of cells competent for the synthesis of the 64K collagen is also discussed.
机译:最近已经证明了通过培养的鸡胚软骨细胞合成新的低分子量胶原蛋白(Capasso等人,Exp.Cell Res.142:197-206,1982; Gibson等人,J.Cell Biol.93。 :1982年; 767:774; Schmid和Conrad,J.Biol.Chem.257:12444-12450,1982)。在本文中,我们报告了在发育中的鸡胚中合成这种新胶原蛋白(64K胶原蛋白)的软骨细胞的定位结果。通过浓缩在9天大的骨干和17天大的胫骨骨干的细胞,可以大量合成64K胶原。这些区域的特征是软骨基质的重塑,导致用骨组织替代软骨。因此,这种胶原蛋白似乎是软骨细胞特定发育阶段的标志。还讨论了能够合成64K胶原的细胞来源。

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