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首页> 外文期刊>Molecular and Cellular Biology >The Drosophila melanogaster gypsy transposable element encodes putative gene products homologous to retroviral proteins.
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The Drosophila melanogaster gypsy transposable element encodes putative gene products homologous to retroviral proteins.

机译：果蝇的吉普赛转座因子编码与逆转录病毒蛋白同源的推定基因产物。

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摘要

We determined the complete nucleotide sequence of the gypsy element present at the forked locus of Drosophila melanogaster in the f1 allele. The gypsy element shares more homology with vertebrate retroviruses than with the copia element of D. melanogaster or the Ty element of Saccharomyces cerevisiae, both in overall organization and at the DNA sequence level. This transposable element is 7,469 base pairs long and encodes three putative protein products. The long terminal repeats are 482 nucleotides long and contain transcription initiation and termination signals; sequences homologous to the polypurine tract and tRNA primer binding site of retroviruses are located adjacent to the long terminal repeats. The central region of the element contains three different open reading frames. The second one encodes a putative protein which shows extensive amino acid homology to retroviral proteins, including gag-specific protease, reverse transcriptase, and DNA endonuclease.
机译：我们确定了在f1等位基因中果蝇果蝇的分叉基因座上存在的吉普赛元素的完整核苷酸序列。在整体组织和DNA序列水平上，吉普赛人与脊椎动物逆转录病毒的同源性比黑腹果蝇的Copia要素或酿酒酵母的Ty要素更高。该转座子的长度为7,469个碱基对，编码三种推定的蛋白质产物。长末端重复序列长482个核苷酸，并包含转录起始和终止信号。与逆转录病毒的多嘌呤束和tRNA引物结合位点同源的序列位于长末端重复序列附近。元素的中央区域包含三个不同的开放阅读框。第二种编码的推定蛋白与逆转录病毒蛋白具有广泛的氨基酸同源性，包括gag特异性蛋白酶，逆转录酶和DNA核酸内切酶。

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