Alternative splicing of the platelet-derived growth factor A-chain transcript occurs in normal as well as tumor cells and is conserved among mammalian species.

B Matoskova; F Rorsman; V Svensson; C Betsholtz

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Alternative splicing of the platelet-derived growth factor A-chain transcript occurs in normal as well as tumor cells and is conserved among mammalian species.

机译：血小板衍生的生长因子A链转录物的选择性剪接发生在正常细胞和肿瘤细胞中，并且在哺乳动物物种中是保守的。

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Using a polymerase chain reaction approach, we have analyzed the alternative usage of the platelet-derived growth factor A-chain exon 6 in mRNA from various cell types. The results show that this sequence is utilized in a small fraction of the mRNA molecules in normal as well as transformed cells and that this phenomenon is conserved among mammalian species.

机译：使用聚合酶链反应方法，我们分析了血小板衍生的生长因子A链外显子6在各种细胞类型的mRNA中的替代用法。结果表明，该序列在正常细胞和转化细胞中的一小部分mRNA分子中都得到利用，并且这种现象在哺乳动物物种中得到了保留。

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《Molecular and Cellular Biology》 |1989年第7期|共3页
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B Matoskova; F Rorsman; V Svensson; C Betsholtz;
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中图分类细胞生物学;
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1. Alternatively spliced platelet-derived growth factor A-chain transcripts are not tumor specific but encode normal cellular proteins. [J] . R M Young, A E Mendoza, T Collins, Molecular and Cellular Biology . 1990,第11期

机译：备选地，剪接的血小板衍生的生长因子A链转录物不是肿瘤特异性的，而是编码正常的细胞蛋白。
2. Betaxolol inhibits extracellular signal-regulated kinase and P70S6 kinase activities and gene expressions of platelet-derived growth factor A-chain and transforming growth factor-beta1 in Dahl salt-sensitive hypertensive rats. [J] . Kobayashi N, Nakano S, Mori Y, Hypertension research: Official journal of the Japanese Society of Hypertension . 2002,第2期

机译：Betaxolol抑制Dahl盐敏感性高血压大鼠的细胞外信号调节激酶和P70S6激酶活性以及血小板源性生长因子A链和转化生长因子β1的基因表达。
3. Effect of methylene methylimino linkage of antisense oligonucleotide to the platelet-derived growth factor A-chain on growth of vascular smooth muscle cells from spontaneously hypertensive rats. [J] . Kishioka H, Fukuda N, Nakayama M, European Journal of Pharmacology: An International Journal . 2000,第3期

机译：反义寡核苷酸的亚甲基甲基亚氨基连接到血小板衍生的生长因子A链对自发性高血压大鼠血管平滑肌细胞生长的影响。
4. Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes [C] . Richard E. Green, Benjamin P. Lewis, R. Tyler Hillman, International Conference on Intelligent Systems for Molecular biology . 2003

机译：普遍预测的无意义介导的mRNA衰减的人正常和疾病基因的替代剪接转录物
5. Characterization of evolutionarily conserved mammalian alternative splicing and alternative promoters [D] . Baek, Daehyun. 2007

机译：进化保守的哺乳动物替代剪接和替代启动子的表征
6. Alternative splicing of the platelet-derived growth factor A-chain transcript occurs in normal as well as tumor cells and is conserved among mammalian species. [O] . B Matoskova, F Rorsman, V Svensson, 1989

机译：血小板衍生的生长因子A链转录物的选择性剪接发生在正常细胞和肿瘤细胞中并且在哺乳动物物种中是保守的。
7. Alternative splicing of the platelet-derived growth factor A-chain transcript occurs in normal as well as tumor cells and is conserved among mammalian species. [O] . Matoskova, B, Rorsman, F, Svensson, V, 1989

机译：血小板衍生的生长因子A链转录物的选择性剪接发生在正常细胞和肿瘤细胞中，并且在哺乳动物物种中是保守的。
8. Initial Biochemical Characterization of Cells Derived from Human Periodontium and Their In vitro Response to Platelet-Derived Growth Factor, Epidermal Growth Factor and Transforming Growth Factor-Beta [R] . Piche', J. E. 1988

机译：人牙周组织细胞的初步生化特征及其对血小板衍生生长因子，表皮生长因子和转化生长因子-β的体外反应

Alternative splicing of the platelet-derived growth factor A-chain transcript occurs in normal as well as tumor cells and is conserved among mammalian species.

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