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首页> 外文期刊>Molecular and Cellular Biology >Disruption of Ini1 Leads to Peri-Implantation Lethality and Tumorigenesis in Mice
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Disruption of Ini1 Leads to Peri-Implantation Lethality and Tumorigenesis in Mice

机译：Ini1的破坏导致小鼠围植入期致死率和致瘤性。

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SNF5/INI1 is a component of the ATP-dependent chromatin remodeling enzyme family SWI/SNF. Germ line mutations ofINI1 have been identified in children with brain and renal rhabdoid tumors, indicating that INI1 is a tumor suppressor. Here we report that disruption of Ini1 expression in mice results in early embryonic lethality. Ini1-null embryos die between 3.5 and 5.5 days postcoitum, and Ini1-null blastocysts fail to hatch, form the trophectoderm, or expand the inner cell mass when cultured in vitro. Furthermore, we report that approximately 15% ofIni1-heterozygous mice present with tumors, mostly undifferentiated or poorly differentiated sarcomas. Tumor formation is associated with a loss of heterozygocity at the Ini1 locus, characterizing Ini1 as a tumor suppressor in mice. Thus, Ini1 is essential for embryo viability and for repression of oncogenesis in the adult organism.
机译：SNF5 / INI1是ATP依赖的染色质重塑酶家族SWI / SNF的组成部分。在患有脑和肾横纹肌瘤的儿童中已鉴定出 INI1 的生殖系突变，表明INI1是一种抑癌基因。在这里，我们报告破坏 Ini1 在小鼠中的表达会导致早期的胚胎致死率。 Ini1 -无效胚在死后3.5至5.5天之间死亡， Ini1 -无效胚泡在体外培养时无法孵化，形成滋养外胚层或扩大内部细胞团。此外，我们报告说，大约有15％的 Ini1 -杂合子小鼠患有肿瘤，大多数是未分化或分化差的肉瘤。肿瘤的形成与 Ini1 位点杂合性的丧失有关，从而将Ini1表征为小鼠的肿瘤抑制因子。因此，Ini1对于成年生物体内的胚胎生存力和抑制肿瘤发生至关重要。

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