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首页> 外文期刊>Molecular and Cellular Biology >A Novel Interferon Regulatory Factor (IRF), IRF-10, Has a Unique Role in Immune Defense and Is Induced by the v-Rel Oncoprotein
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A Novel Interferon Regulatory Factor (IRF), IRF-10, Has a Unique Role in Immune Defense and Is Induced by the v-Rel Oncoprotein

机译：新型干扰素调节因子（IRF-10）在免疫防御中具有独特作用，并由v-Rel癌蛋白诱导

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The cloning and functional characterization of a novel interferon regulatory factor (IRF), IRF-10, are described. IRF-10 is most closely related to IRF-4 but differs in both its constitutive and inducible expression. The expression of IRF-10 is inducible by interferons (IFNs) and by concanavalin A. In contrast to that of other IRFs, the inducible expression of IRF-10 is characterized by delayed kinetics and requires protein synthesis, suggesting a unique role in the later stages of an antiviral defense. Accordingly, IRF-10 is involved in the upregulation of two primary IFN-γ target genes (major histocompatibility complex [MHC] class I and guanylate-binding protein) and interferes with the induction of the type I IFN target gene for 2′,5′-oligo(A) synthetase. IRF-10 binds the interferon-stimulated response element site of the MHC class I promoter. In contrast to that of IRF-1, which has some of the same functional characteristics, the expression of IRF-10 is not cytotoxic for fibroblasts or B cells. The expression of IRF-10 is induced by the oncogene v-rel, the proto-oncogene c-rel, and IRF-4 in a tissue-specific manner. Moreover, v-Rel and IRF-4 synergistically cooperate in the induction of IRF-10 in fibroblasts. The level of IRF-10 induction in lymphoid cell lines by Rel proteins correlates with Rel transformation potential. These results suggest that IRF-10 plays a role in the late stages of an immune defense by regulating the expression some of the IFN-γ target genes in the absence of a cytotoxic effect. Furthermore, IRF-10 expression is regulated, at least in part, by members of the Rel/NF-κB and IRF families.
机译：描述了新型干扰素调节因子（IRF）IRF-10的克隆和功能鉴定。 IRF-10与IRF-4关系最密切，但其组成型和诱导型表达均不同。 IRF-10的表达可被干扰素（IFN）和伴刀豆球蛋白A诱导。与其他IRF的表达相反，IRF-10的可诱导表达具有动力学延迟的特点，并且需要蛋白质合成，这暗示了IRF-10的独特作用。抗病毒防御的各个阶段。因此，IRF-10参与两个主要IFN-γ靶基因（主要组织相容性复合物[MHC] I类和鸟苷酸结合蛋白）的上调，并干扰2'，5的I型IFN靶基因的诱导。 ′-寡聚（A）合成酶。 IRF-10结合I类MHC启动子的干扰素刺激反应位点。与具有某些相同功能特征的IRF-1相比，IRF-10的表达对成纤维细胞或B细胞无细胞毒性。癌基因v- rel ，原癌基因c- rel 和IRF-4以组织特异性方式诱导IRF-10的表达。此外，v-Rel和IRF-4在成纤维细胞中诱导IRF-10协同作用。 Rel蛋白在淋巴样细胞系中诱导IRF-10的水平与Rel转化潜能相关。这些结果表明，IRF-10在不具有细胞毒性作用的情况下通过调节某些IFN-γ靶基因的表达在免疫防御的后期起作用。此外，IRF-10表达至少部分受Rel /NF-κB和IRF家族成员的调节。

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