Extensive editing of CR2 maxicircle transcripts of Trypanosoma brucei predicts a protein with homology to a subunit of NADH dehydrogenase.

A E Souza; H H Shu; L K Read; P J Myler; K D Stuart

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Extensive editing of CR2 maxicircle transcripts of Trypanosoma brucei predicts a protein with homology to a subunit of NADH dehydrogenase.

机译：布鲁氏锥虫CR2上环最大转录本的广泛编辑预测一种与NADH脱氢酶亚基同源的蛋白。

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Several genes of the Trypanosoma brucei mitochondrial genome (the maxicircle) encode mRNAs that are so extensively altered by RNA editing that the gene cannot be identified by analysis of the DNA sequence. The 322-nucleotide preedited RNA of one of these genes, CR2, is converted into a 647-nucleotide transcript by the addition of 345 uridines and the deletion of 20 genomically encoded uridines. The fully edited transcript has an open reading frame that predicts a 194-amino-acid protein. This protein, which we name ND9 (NADH dehydrogenase subunit 9), has homology to a subunit of NADH dehydrogenase (respiratory complex I). Seven guide RNAs that can specify edited CR2 sequence have been identified. Steady-state levels of unedited ND9 transcripts are greater in bloodstream than in procyclic forms, but edited ND9 mRNA is present in similar abundance in both life cycle stages.

机译：布鲁氏锥虫线粒体基因组（最大圆）的几个基因编码的mRNA被RNA编辑广泛改变，以致无法通过分析DNA序列来鉴定该基因。通过添加345个尿苷和删除20个基因组编码的尿苷，可以将其中一个基因CR2的322个核苷酸的预编辑RNA转换为647个核苷酸的转录本。经过完全编辑的转录本具有一个开放阅读框，可预测194个氨基酸的蛋白质。我们将此蛋白命名为ND9（NADH脱氢酶亚基9），与NADH脱氢酶（呼吸复合体I）的亚基具有同源性。已经确定了七个可以指定编辑的CR2序列的指导RNA。血液中未经编辑的ND9转录本的稳态水平要高于前环形式，但在两个生命周期阶段中，经过编辑的ND9 mRNA的丰度都相似。

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《Molecular and Cellular Biology》 |1993年第11期|共9页
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A E Souza; H H Shu; L K Read; P J Myler; K D Stuart;
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1. Maxicircle CR1 transcripts of Trypanosoma brucei are edited and developmentally regulated and encode a putative iron-sulfur protein homologous to an NADH dehydrogenase subunit. [J] . A E Souza, P J Myler, K Stuart Molecular and Cellular Biology . 1992,第5期

机译：布鲁氏锥虫的Maxicircle CR1转录物被编辑和发展调节，并编码与NADH脱氢酶亚基同源的推定的铁硫蛋白。
2. Editing of Trypanosoma brucei maxicircle CR5 mRNA generates variable carboxy terminal predicted protein sequences [J] . Kenneth D. Wilson, Kenneth Stuart, Laurie K. Read, Nucleic acids research . 1994,第8期

机译：布鲁氏锥虫Maxicircle CR5 mRNA的编辑产生可变的羧基末端预测蛋白序列
3. Localization of kinetoplast DNA maxicircle transcripts in bloodstream and procyclic form Trypanosoma brucei. [J] . K D Stuart, S B Gelvin Molecular and Cellular Biology . 1982,第7期

机译：运动和DNA形式的布鲁氏锥虫的动塑料DNA最大环转录本的定位。
4. GLOBAL ANALYSIS OF PROTEIN COMPLEXES IN TRYPANOSOMA BRUCEI USING CROSS-LINKING MASS SPECTROMETRY [C] . Fernando Almeida, Michele Tinti, Michael Ferguson International Mass Spectrometry Conference . 2018

机译：交联质谱法全球蛋白质复合物的蛋白质复合物
5. Structural studies of RNA-editing proteins in Trypanosoma brucei. [D] . Wu, Mei-Ting. 2010

机译：布氏锥虫RNA编辑蛋白的结构研究。
6. Extensive editing of CR2 maxicircle transcripts of Trypanosoma brucei predicts a protein with homology to a subunit of NADH dehydrogenase. [O] . A E Souza, H H Shu, L K Read, 1993

机译：布鲁氏锥虫CR2上环最大转录本的广泛编辑预测一种与NADH脱氢酶亚基同源的蛋白。
7. Extensive editing of CR2 maxicircle transcripts of Trypanosoma brucei predicts a protein with homology to a subunit of NADH dehydrogenase. [O] . Souza, A E, Shu, H H, Read, L K, 1993

机译：布鲁氏锥虫CR2上环最大转录本的广泛编辑预测一种与NADH脱氢酶亚基同源的蛋白。

Extensive editing of CR2 maxicircle transcripts of Trypanosoma brucei predicts a protein with homology to a subunit of NADH dehydrogenase.

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