A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregation.

W E Payne; M Fitzgerald-Hayes

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A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregation.

机译：PLC1中的突变是酿酒酵母的一种特定的磷酸肌醇特异性磷脂酶C基因，可导致异常的有丝分裂染色体分离。

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We identified a putative Saccharomyces cerevisiae homolog of a phosphoinositide-specific phospholipase C (PI-PLC) gene, PLC1, which encodes a protein most similar to the delta class of PI-PLC enzymes. The PLC1 gene was isolated during a study of yeast strains that exhibit defects in chromosome segregation. plc1-1 cells showed a 10-fold increase in aberrant chromosome segregation compared with the wild type. Molecular analysis revealed that PLC1 encodes a predicted protein of 101 kDa with approximately 50 and 26% identity to the highly conserved X and Y domains of PI-PLC isozymes from humans, bovines, rats, and Drosophila melanogaster. The putative yeast protein also contains a consensus EF-hand domain that is predicted to bind calcium. Interestingly, the temperature-sensitive and chromosome missegregation phenotypes exhibited by plc1-1 cells were partially suppressed by exogenous calcium.

机译：我们确定了磷酸肌醇特异性磷脂酶C（PI-PLC）基因，PLC1的推定的啤酒酵母同源物，其编码最类似于PI-PLC酶的delta类的蛋白质。在研究显示染色体分离缺陷的酵母菌株过程中分离了PLC1基因。与野生型相比，plc1-1细胞的异常染色体分离增加了10倍。分子分析表明，PLC1编码的预测蛋白质为101 kDa，与人，牛，大鼠和果蝇果蝇PI-PLC同工酶的高度保守的X和Y结构域具有大约50％和26％的同一性。推定的酵母蛋白还包含一个共有的EF-手结构域，预计将与钙结合。有趣的是，外源钙部分抑制了plc1-1细胞表现出的温度敏感性和染色体错聚表型。

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《Molecular and Cellular Biology》 |1993年第7期|共14页
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W E Payne; M Fitzgerald-Hayes;
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1. In vivo analysis of the Saccharomyces cerevisiae centromere CDEIII sequence: requirements for mitotic chromosome segregation. [J] . B Jehn, R Niedenthal, J H Hegemann Molecular and Cellular Biology . 1991,第10期

机译：酿酒酵母CDEIII序列的体内分析：有丝分裂染色体分离的要求。
2. Mutations in CEN3 cause aberrant chromosome segregation during meiosis in Saccharomyces cerevisiae. [J] . A Gaudet, M Fitzgerald-Hayes Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 1989,第3期

机译：CEN3突变导致酿酒酵母减数分裂过程中异常的染色体分离。
3. Single base-pair mutations in centromere element III cause aberrant chromosome segregation in Saccharomyces cerevisiae. [J] . J McGrew, B Diehl, M Fitzgerald-Hayes Molecular and Cellular Biology . 1986,第2期

机译：着丝粒元素III中的单个碱基对突变会导致酿酒酵母中异常的染色体分离。
4. Disruption of PDC1 Gene to Enhance Pyruvic Acid Accumulation of Saccharomyces cerevisiae - Subtitle: PDC1 disruption for pyruvate accumulatin of S. cerevisiae [C] . WANG De-pei, DING Xin, DENG Xu-heng, International Conference on Bioinformatics and Biomedical Engineering . 2010

机译：PDC1基因的破坏，增强酿酒酵母酿酒酵母的丙酮酸积累 - 杂志：PDC1丙二属藜亚氏菌累积蛋白的破坏
5. PLC1 genetically interacts with the mitotic spindle checkpoint and the chromatin remodeling machinery in Saccharomyces cerevisiae. [D] . DeLillo, Nicholas Joseph, Jr. 2003

机译：PLC1与酿酒酵母中的有丝分裂纺锤体检查点和染色质重塑机制发生遗传相互作用。
6. A mutation in PLC1 a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae causes aberrant mitotic chromosome segregation. [O] . W E Payne, M Fitzgerald-Hayes 1993

机译：PLC1中的突变是一种来自酿酒酵母的候选磷酸肌醇特异性磷脂酶C基因导致异常的有丝分裂染色体分离。
7. A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregation. [O] . Payne, W E, Fitzgerald-Hayes, M 1993

机译：PLC1中的突变是一种来自酿酒酵母的候选磷酸肌醇特异性磷脂酶C基因，导致异常的有丝分裂染色体分离。

A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregation.

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