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首页> 外文期刊>Molecular and Cellular Biology >EGT2 gene transcription is induced predominantly by Swi5 in early G1.
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EGT2 gene transcription is induced predominantly by Swi5 in early G1.

机译：EGT2基因转录主要由早期G1中的Swi5诱导。

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In a screen for cell cycle-regulated genes in the yeast Saccharomyces cerevisiae, we have identified a gene, EGT2, which is involved in cell separation in the G1 stage of the cell cycle. Transcription of EGT2 is tightly regulated in a cell cycle-dependent manner. Transcriptional levels peak at the boundary of mitosis and early G1 The transcription factors responsible for EGT2 expression in early G1 are Swi5 and, to a lesser extent, Ace2. Swi5 is involved in the transcriptional activation of the HO gene during late G1 and early S phase, and Ace2 induces CTS1 transcription during early and late G1 We show that Swi5 activates EGT2 transcription as soon as it enters the nucleus at the end of mitosis in a concentration-dependent manner. Since Swi5 is unstable in the nucleus, its level drops rapidly, causing termination of EGT2 transcription before cells are committed to the next cell cycle. However, Swi5 is still able to activate transcription of HO in late G1 in conjunction with additional activators such as Swi4 and Swi6.
机译：在对酿酒酵母中细胞周期调控基因的筛选中，我们鉴定了一个基因EGT2，该基因与细胞周期G1期的细胞分离有关。 EGT2的转录以细胞周期依赖性方式受到严格调控。转录水平在有丝分裂和早期G1的边界处达到峰值。在早期G1中负责EGT2表达的转录因子是Swi5，在较小程度上是Ace2。 Swi5在G1晚期和S早期阶段参与HO基因的转录激活，而Ace2在G1早期和G1晚期诱导CTS1转录。我们证明Swi5一旦进入有丝分裂末期的细胞核，就会激活EGT2转录。浓度依赖性的方式。由于Swi5在细胞核中不稳定，因此其水平迅速下降，导致EGT2转录终止，然后细胞才进入下一个细胞周期。但是，Swi5仍然能够与其他激活剂（例如Swi4和Swi6）一起激活G1晚期的HO转录。

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