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首页> 外文期刊>Molecular and Cellular Biology >per mRNA cycling is locked to lights-off under photoperiodic conditions that support circadian feedback loop function.
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per mRNA cycling is locked to lights-off under photoperiodic conditions that support circadian feedback loop function.

机译：在支持生物钟反馈回路功能的光周期条件下，每个mRNA循环均被锁定为熄灭状态。

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Circadian fluctuations in per mRNA and protein are central to the operation of a negative feedback loop that is necessary for setting the free-running period and for entraining the circadian oscillator to light-dark cycles. In this study, per mRNA cycling and locomotor activity rhythms were measured under different light and dark cycling regimes to determine how photoperiods affect the molecular feedback loop and circadian behavior, respectively. These experiments reveal that per mRNA peaks in abundance 4 h after lights-off in photoperiods of < or = 16 h, that, phase shifts in per mRNA cycling and behavioral rhythmicity occur rapidly after flies are transferred from one photoperiod to another, and that photoperiods longer than 20 h abolish locomotor activity rhythms and leave per mRNA at a median constitutive level. These results indicate that the per feedback loop uses lights-off as a phase reference point and suggest (along with previous findings for per01 and tim01) that per mRNA cycling is not regulated via simple negative feedback from the per protein.
机译：每个mRNA和蛋白质的昼夜节律波动对于负反馈回路的操作至关重要，这对于设置自由运行时间和将昼夜节律振荡器带至明暗循环是必需的。在这项研究中，在不同的明暗循环条件下测量每个mRNA循环和运动活动节律，以确定光周期分别如何影响分子反馈回路和昼夜节律行为。这些实验表明，在≤16 h的光周期中，点燃后4 h内每个mRNA的峰都丰富，即果蝇从一个光周期转移到另一个光周期后，每个mRNA周期的相移和行为节律迅速发生，并且光周期超过20小时，运动活动节律消失，每个mRNA处于中位组成水平。这些结果表明，每个反馈环使用熄灯作为相位参考点，并暗示（连同以前对per01和tim01的发现），每个mRNA的循环不受单个蛋白的简单负反馈调控。

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