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首页> 外文期刊>Molecular and Cellular Biology >Hepatocyte Nuclear Factor 3β (Foxa2) Is Dispensable for Maintaining the Differentiated State of the Adult Hepatocyte
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Hepatocyte Nuclear Factor 3β (Foxa2) Is Dispensable for Maintaining the Differentiated State of the Adult Hepatocyte

机译：肝细胞核因子3β（Foxa2）可用于维持成年肝细胞的分化状态

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摘要

Liver-specific gene expression is controlled by a heterogeneous group of hepatocyte-enriched transcription factors. One of these, the winged helix transcription factor hepatocyte nuclear factor 3β (HNF3β or Foxa2) is essential for multiple stages of embryonic development. Recently, HNF3β has been shown to be an important regulator of other hepatocyte-enriched transcription factors as well as the expression of liver-specific structural genes. We have addressed the role of HNF3β in maintenance of the hepatocyte phenotype by inactivation ofHNF3β in the liver. Remarkably, adult mice lackingHNF3β expression specifically in hepatocytes are viable, with histologically normal livers and normal liver function. Moreover, analysis of >8,000 mRNAs by array hybridization revealed that lack ofHNF3β affects the expression of only very few genes. Based on earlier work it appears that HNF3β plays a critical role in early liver development; however, our studies demonstrate that HNF3β is not required for maintenance of the adult hepatocyte or for normal liver function. This is the first example of such functional dichotomy for a tissue specification transcription factor.
机译：肝脏特异性基因表达由富含肝细胞的转录因子的异质组控制。其中之一，翅螺旋转录因子肝细胞核因子3β（HNF3β或 Foxa2 ）对于胚胎发育的多个阶段至关重要。最近，HNF3β已被证明是其他富含肝细胞的转录因子以及肝脏特异性结构基因表达的重要调节剂。我们已经解决了HNF3β在肝脏中HNF3β失活在维持肝细胞表型中的作用。值得注意的是，在肝细胞中特异性缺乏HNF3β表达的成年小鼠是可行的，肝脏组织学正常，肝功能正常。而且，通过阵列杂交对> 8,000个mRNA的分析表明，HNF3β的缺乏仅影响极少数基因的表达。根据早期工作，似乎HNF3β在早期肝脏发育中起关键作用。然而，我们的研究表明，HNF3β不需要维持成人肝细胞或正常肝功能。这是针对组织规格转录因子的这种功能二分法的第一个例子。

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