Drosophila Med6 Is Required for Elevated Expression of a Large but Distinct Set of Developmentally Regulated Genes

Byung Soo Gim; Jin Mo Park; Jeong Ho Yoon; Changwon Kang; Young-Joon Kim

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Drosophila Med6 Is Required for Elevated Expression of a Large but Distinct Set of Developmentally Regulated Genes

机译：果蝇Med6是大但不同的发育调控基因集的高表达所需的。

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Mediator is the evolutionarily conserved coactivator required for the integration and recruitment of diverse regulatory signals to basal transcription machinery. To elucidate the functions of metazoan Mediator, we isolated Drosophila melanogaster Med6mutants. dMed6 is essential for viability and/or proliferation of most cells. dMed6 mutants failed to pupate and died in the third larval instar with severe proliferation defects in imaginal discs and other larval mitotic cells. cDNA microarray, quantitative reverse transcription-PCR, and in situ expression analyses of developmentally regulated genes indMed6 mutants showed that transcriptional activation of many, but not all, genes was affected. Among the genes found to be affected were some that play a role in cell proliferation and metabolism. Therefore, dMed6 is required in most cells for transcriptional regulation of many genes important for diverse aspects of Drosophila development.

机译：介体是将多种调控信号整合和募集到基础转录机制所需的进化保守的共激活子。为了阐明后生介体的功能，我们分离了果蝇Med6 突变体。 dMed6 对于大多数细胞的生存能力和/或增殖至关重要。 dMed6 突变体化脓失败，并在第三龄幼虫期死亡，在假牙盘和其他幼虫有丝分裂细胞中出现严重的增殖缺陷。 cDNA微阵列，定量逆转录PCR和 dMed6 突变体中发育调控基因的原位表达分析表明，许多（但不是全部）基因的转录激活受到影响。在发现受影响的基因中，有一些在细胞增殖和代谢中起作用。因此， dMed6 在大多数细胞中是转录调控果蝇发育的许多重要基因所需的。 展开▼

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《Molecular and Cellular Biology》 |2001年第15期|共14页

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Byung Soo Gim; Jin Mo Park; Jeong Ho Yoon; Changwon Kang; Young-Joon Kim;
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中图分类细胞生物学;

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Drosophila Med6 Is Required for Elevated Expression of a Large but Distinct Set of Developmentally Regulated Genes

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